Cancer Currents for March 2010

News and Notes from the Director
"Know Your Chances: Understanding Cancer Risk" (March 9, 2010 at 7:00 p.m.)
Photo: Lisa Schwartz and Steve Woloshin

Lisa Schwartz, MD, and Steve Woloshin, MD

Every day, the general public is bombarded by television ads, public service announcements, and media reports warning of dire risks to their health and offering solutions to help lower those risks. Lisa Schwartz, MD, and Steve Woloshin, MD, will help them understand how to interpret these messages in order to assess their own cancer risk and put health concerns into perspective. Schwartz and Woloshin-general internists and faculty members at Dartmouth Medical School-are well-known experts in risk analysis. Presented by the Friends of Norris Cotton Cancer Center.

New and Upcoming Grant Deadlines
  • The Fiscal Year 2010 Defense Appropriations Act provides $150 million to the Department of Defense Breast Cancer Research Program to promote innovative research focused on eradicating breast cancer. Several Awards available, pre-application deadlines begin March 18, 2010. More information.
  • ACS Area of Special Interest: "The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection, and Treatment." Applications are accepted until April 1, 2010. Application and more information at
Save the Date: Colon Health Expo (March 18, 2010)
Photo: Colon Health Expo

On March 18 from 11:00 a.m. to 3:00 p.m., in the Main Entrance Rotunda of DHMC, Norris Cotton Cancer Center and the DHMC Section of Gastroenterology and Hepatology will be hosting a free prevention program for the public in honor of National Colorectal Cancer Awareness Month. The fair will feature information about screening options, surgical treatment for colorectal cancer, risk assessment, and tips on healthy lifestyles to help prevent colon cancer. No pre-registration is necessary.

Genomics & Microarray Laboratory Now Offering Deep Sequencing

The Dartmouth Genomics & Microarray Laboratory recently purchased the Illumina Genome Analyzer II for second generation (deep sequencing) sequencing. The lab now offers the means for the complete sequencing of genomic DNA and all RNA transcripts. The Illumina Genome Analyzer II at Dartmouth will offer the ability to pinpoint genetic mutations and variations associated with phenotypes, determine the genomic locations bound by specific DNA-binding proteins, identify and quantify differences in mRNA expression as a function of environmental and disease conditions, and many other applications. The computational infrastructure is in place to provide extensive bioinformatics support for sequence assembly and analysis to enable innovative and high impact science.

Cancer Center Members to Speak at NH Comprehensive Cancer Collaboration Annual Conference (March 31, 2010)
Photo: Ardis Olson, MD Photo: Lynn F. Butterly, MD

Ardis Olson, MD and Lynn Butterly, MD

The New Hamphire Comprehensive Cancer Collaboration's fifth Annual Conference (NH CCC), titled "Reduce Cancer Risk by Changing Behaviors: What You Can Do," will be held on Wednesday, March 31, 2010 at the Grappone Conference Center, located in the Courtyard by Marriot in Concord, NH. For more information and to register, visit

Ardis Olson, MD; Lynn Butterly, MD; and Joanne Gersten, RN, MS, will be speaking at this year's NH CCC Annual Conference. Olson will present new research about what influences teens, and ways to change health risk behaviors. Butterly and Gersten will present on their work on the NH Colorectal Cancer Screening Program, and ways to increase screening through public policy, community health initiatives, and healthcare systems change.

NCI Seeks Feedback for Evolution

In an effort to improve its ability to reach diverse audiences with the latest, evidence-based cancer information, the National Cancer Institute (NCI) recently announced an "evolution" of its flagship resource, The NCI welcomes ideas from individuals and organizations on how to improve and enhance, through an online forum at The dialogue will be open until March 31, 2010. After that date, a new section established on will provide updates on progress and program milestones for the site's evolution. For more information on this effort, please read this NCI Cancer Bulletin.

Third Annual Dartmouth Integrative Biology Symposium: "Clinical & Translational Science" (April 27 - 28, 2010)
Graphic: IB Symposium Logo

The invited speakers to the Third Annual Dartmouth Integrative Biology Symposium are the intellectual and innovative leaders in their respective fields of genomics, proteomics, biostatistics, bioinformatics, and systems biology. The purpose of the symposium is to make the research and medical communities aware of the latest cutting-edge ideas and progress in systems biology and translational research, and to raise awareness of the exciting advances in integrative biology at Dartmouth.

Submit a poster for the Poster Session: present your latest research results on the evening of Tuesday, April 27, and meet with leaders in the fields of Integrative Biology and Translational Science, including keynote speaker Dr. Richard K. Wilson, Director of the Genome Sequencing Center at Washington University. All research projects are welcome. New this year are iPads as prizes for the top three posters (and three drawings for iPads during the symposium for registered medical and graduate students).

Compton, Dmitrovsky Paper Featured on Cover of Journal
Photo: Duane Compton, PhD Photo: Ethan Dmitrovsky, MD

Duane Compton, PhD, and Ethan Dmitrovsky, MD

Duane Compton, PhD, and Ethan Dmitrovsky, MD, recently authored a paper that was featured on the cover of Clinical Cancer Research, a journal published by the American Association for Cancer Research. Compton is Associate Director of Basic Sciences and Director of the Cancer Mechanisms Research Program at the Cancer Center, and Dmitrovsky is Co-Director of the Cancer Epidemiology and Chemoprevention Research Program and also a member of Cancer Mechanisms. Their paper, "Targeting the Cyclin E-Cdk-2 Complex Represses Lung Cancer Growth by Triggering Anaphase Catastrophe", can be found on the journal's website.

-Mark Israel, MD