Breast Cancer Gene Signature Predicts Bladder Cancer Progression
June 25, 2015
Investigators harnessed genomic data to discover that the previously identified E2F4 signature in breast cancer can be utilized to predict prognosis and response to therapy in bladder cancer...Read more.
Researchers Determine How Melanoma Tumors Evade Immune System
June 18, 2015
In a mouse model of melanoma, investigators from Norris Cotton Cancer Center found that chemo-attractive signals that direct immune cells into tumors are actively suppressed by the cancer...Read more.
Using Gene Sets to Predict Survival in Breast Cancer Patients
June 17, 2015
Dartmouth researchers develop new method to provide a deeper understanding of the genetic component of cancer...Read more.
Mohs Surgery Decisions Should Include Patients' Preferences
June 12, 2015
Dartmouth investigators' research demonstrates that a fraction of the transected squamous cell carcinomas in situ referred for Mohs surgeries have an invasive component...Read more.
Integrating Genomic Data to Make Inferences in Breast Cancer
June 12, 2015
Harnessing Dartmouth's Discovery supercomputer and high-throughput genomic data, investigators found non-random tendencies for transcription factors to be involved in several types of cancer...Read more.
Common Cancer Drug Increases Collagen in Melanoma Tumors
May 27, 2015
The question remains whether Vemurafenib, the common drug for patients with BRAFV600E melanoma, is helping to slow down tumor progression, or is an off-target effect of the drug...Read more.
Monitoring Oxygen in Glioma to Improve Treatment Outcomes
May 26, 2015
Implantable micro-device monitors oxygen levels in the brain to help selectively inhibit aggressive tumor growth with a rational use of gemcitabine and cell cycle checkpoint inhibitor in treatment..Read more.
Dartmouth Physician Wins Conquer Cancer Foundation/ASCO Career Development Award
May 26, 2015
Florian Schroeck, MD, MS receives national ASCO's Conquer Cancer Foundation Career Development award to study differences between low-risk and high-risk bladder cancers...Read more.
Dartmouth Researchers Engineer Drug Micro-factory to Attack Tumor
May 14, 2015
A team of Dartmouth investigators have engineered therapeutic cells encapsulated in nanoporous capsules to secrete antitumor molecules from within the tumor...Read more.
Food Dye, Near Infrared Light Can Aid in Breast Resection
May 12, 2015
Dartmouth team focuses on coming up with a practical solution that both preserves the surgical practice of inking the margins of breast cancer tumors, and allows quality imaging post-inking...Read more.
Small Molecule Stimulates TRAIL-induced Apoptosis in Cancer Cells
May 08, 2015
Harnessing apoptosis, a natural cell death process to eliminate damaged cells, has long been a key strategy in cancer research...Read more.
Protein MCL1 Prevents Cell Death to Prolong Anti-virus Response
May 07, 2015
The mechanisms of long-term immunity from viruses that we've fought off may be key to protection against cancer, according to a study led by Dartmouth's Norris Cotton Cancer Center investigators...Read more.
Dartmouth, UVM Research Shares Resources to Boost Investigations
May 04, 2015
The Memorandum of Agreement facilitates investigators' access to new services from known and reputable scientists at each institution...Read more.
Mixing Energy Drinks, Alcohol Tied to Abusive Drinking in Teens
April 30, 2015
Norris Cotton Cancer Center investigators found teens aged 15-17 years old who had ever mixed alcohol with energy drinks were four times more likely to meet the criteria for alcohol use disorder...Read more.
Prouty Participants See Progress in Fight Against Cancer
April 29, 2015
As participants prepare for the annual Prouty cancer fundraiser July 10-11, they have new evidence of the difference they have made in finding a cure...Read more.
Dartmouth Investigators Provide Insight at AACR Meeting
April 22, 2015
Dartmouth's delegation is sharing their cancer findings in areas as diverse as immunology, ovarian cancer, and glioblastoma, in a variety of formats during the course of the AACR's Annual Meeting...Read more.
Prostate Cancer Treatment in New Hampshire Evolves with New Understanding, Technology
April 17, 2015
There are signs of improved treatments for prostate cancer among New Hampshire men, according to a recent Dartmouth-Hitchcock Norris Cotton Cancer Center study...Read more.
Research Finds No Correlation between Regulatory T Cells and Survival in Glioblastoma
April 16, 2015
Using a novel methodology of epigenetic quantitative analysis, investigators found no correlation between regulatory T cells and survival in the tumor microenvironment or blood, even when adjusting for well-known prognostic factors. ..Read more.
Early Use of Palliative Care in Cancer Improves Patients' Lives, Outcomes for Caregivers
April 15, 2015
A new randomized clinical trial notes significant improvement in several measures among those who began palliative care early...Read more.
Reconceptualizing Stress in Cancer Treatment
April 14, 2015
Dartmouth investigators point to the shortcomings of using the word stress in a medical or scientific context and encourage bodymind therapies to treat trauma in patients with cancer...Read more.
Nanoparticles at Specific Temperature Stimulate Antitumor Response
April 13, 2015
Dartmouth researchers identified the precise temperature that results in a distinct body-wide antitumor immune response that resists metastatic disease...Read more.
Specific Cells in Female Reproductive Tract Display Susceptibility to HIV Infection
April 09, 2015
Dartmouth study finds some portions of the female reproductive tract are more likely to be infected by HIV, particularly the ectocervix compared to the endometrium...Read more.
Investigators Discover Mechanism Responsible for Tumor Invasion in Brain Cancer
April 08, 2015
A neuro-oncology research team at Dartmouth's Norris Cotton Cancer Center recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma...Read more.
Research Finds Cells Respond to Stress by Folding and Unfolding Their Genomes
April 07, 2015
Uncovering cellular response to stress may provide leverage to determine how to trick undesirable cells, such as cancer or damaged cells, into dying instead of recovering from stress. ..Read more.
Dartmouth Investigators Identify Mechanism that Drives Melanoma to Metastasize
April 06, 2015
The significance of this work is its descriptions of alternative mechanisms by which tumors move and settle in new locations...Read more.
Dartmouth Investigators Develop Antibacterial Enzymes to Combat Drug-Resistant Bacterial Pathogen...
April 02, 2015
By engineering antibacterial enzymes, Dartmouth investigators led by Karl Griswold, PhD are using novel strategies to target the prevalent drug-resistant bacterium Staphylococcus aureus...Read more.
"Firefly" Mechanism Makes Cancer Studies More Efficient, Less Expensive
April 01, 2015
Dartmouth investigators use bioluminescence to study response by multiple tumors to therapy...Read more.
Facilitated Intervention Can Improve Quality of Life for Breast Cancer Survivors
March 31, 2015
Taking the focus off pain management and specific post-treatment symptoms, Norris Cotton Cancer Center researchers establish a new paradigm for working with breast cancer survivors...Read more.
Marketing of Energy Drinks Placed on TV Channels that Appeal to Teens
March 30, 2015
Though the Academy of Pediatrics advises against the consumption of energy drinks by teens, research finds that manufacturers market the bulk of their products on TV channels that likely appeal to teens...Read more.
Norris Cotton Cancer Center at Dartmouth Redesignated As NCI "Comprehensive Cancer Center"
March 26, 2015
The National Cancer Institute (NCI) has renewed its Cancer Center Support Grant to Norris Cotton Cancer Center (NCCC) at Dartmouth, continuing NCCC's designation as a Comprehensive Cancer Center...Read more.
Researchers Use Nanoparticles to Selectively Target Tumor Cells in Two Cancer Models
March 25, 2015
Dartmouth team uses nanomaterials to pursue a systematic study of variables in xenograft models of both breast and ovarian human cancer...Read more.
Immunomagnetic Assay On-a-Chip Captures, Analyzes Circulating Tumor Cells
March 24, 2015
Dartmouth bioengineers demonstrate a novel system that couples nano-engineered particles and microfluidic chips for capturing and manipulating circulating tumor cells...Read more.
Researchers Discover Mechanism to Control Multiple Processes of Cell Growth, Division
March 23, 2015
Investigators from Dartmouth's Norris Cotton Cancer Center find that the protein Pom1 possesses the ability to modify different sets of proteins to coordinate the processes of cell growth and division...Read more.
Dartmouth Investigators Make Photodynamic Therapy for Pancreatic Cancer Simpler, Cheaper
March 20, 2015
Research finds the values measured with dynamic contrast enhanced computer tomography strongly correlated with fluorescence intensity measured directly from the pancreatic tissue...Read more.
Two Distinct Populations of CD4 T Cells Play Different Roles in Immune System
March 19, 2015
Utilizing a novel transgenic mouse model, Edward Usherwood, PhD of Dartmouth's Norris Cotton Cancer Center and collaborators found that CD4 T cells divide into two different populations that each has a different job. ..Read more.
mHealth App Ideal for Breast Cancer Risk Assessment, Prevention
March 18, 2015
Elissa Ozanne, PhD from Dartmouth's Norris Cotton Cancer Center and colleagues concluded that mobile health devices are acceptable to older, diverse, and low income women...Read more.
Doctors Don't Always Agree on Breast Biopsies;
Say Women with Aytpia or DCIS Should Seek Second ...
March 17, 2015
While doctors almost always agree on a pathological diagnosis of invasive breast cancer, there is room for improvement when diagnosing atypia (or atypical ductal hyperplasia-ADH) and DCIS (ductal carcinoma in-situ)...Read more.
Dartmouth Investigators Identify Window of Vulnerability for STIs to Infect Human Female Reproduc...
March 16, 2015
The benefits of these findings are directly applicable to other reproductive challenges including gynecological cancers such as cervical cancer...Read more.
Fast Food Commercials to Kids 'Deceptive' by Industry Self-Regulation Standards
March 05, 2015
Fast food ads aimed at kids fail to de-emphasize toy premiums, and fail to emphasize healthy menu items, investigators at Dartmouth-Hitchcock's Norris Cotton Cancer Center have found...Read more.
U.S. Spends More on Cancer Care, Saves Fewer Lives than Western Europe
March 02, 2015
Such findings have raised questions about the additional value of U.S. cancer care derived from the additional spending, in comparison to the situation in other high-income countries...Read more.
Cherenkov Effect Improves Radiation Therapy for Patients with Cancer
February 25, 2015
The complex parts of the blue light known as the Cherenkov Effect can be measured and used in dosimetry to make therapies safer and more effective. ..Read more.
Dartmouth Investigators Discover Key Indicator for Successful Treatment of Infertile Couples
February 20, 2015
Study determines if follicle stimulating hormone and estrogen at the upper limits of normal could predict treatment success as measured in live birth rates. ..Read more.
Structure-based Design Used as Tool for Engineering Deimmunized Biotherapeutics
February 13, 2015
While methods for identifying immunogenic hotspots, or epitopes, are evolving rapidly, technologies to redesign the hotspots while maintaining biotherapeutic activity and stability are far less developed...Read more.
Google-style Ranking Used to Describe Gene Connectivity
February 13, 2015
Using the technique known as "Gene Rank" (GR), Eugene Demidenko, PhD, captured a new characterization of gene connectivity by using a computer algorithm to compare tissues across or within organisms at great speed with a simple laptop computer...Read more.
Investigators at Dartmouth Identify Key Pathways Underlying Different Subsets of Systemic Scleros...
February 10, 2015
Sorting out patients with systemic sclerosis (SSc) according to their shared biology, researchers discovered how disease heterogeneity can be defined, allowing for targeted selection of patients for clinical trials...Read more.
Dartmouth Physician-Scientists Examine Efficacy of Radiation Therapy in 'Good-Risk' DCIS Patients...
February 09, 2015
A collaborative national clinical trials group discovered that radiation therapy in addition to chemotherapy was even more effective at preventing recurrence of ductal carcinoma in situ (DCIS) than previously thought...Read more.
Dartmouth Investigators Find Pilot ACOs Miss Opportunities to Curb Cardiovascular Spending
February 04, 2015
In a study of 10 large health systems, researchers at Dartmouth and the University of Michigan found that implementation of pilot accountable care organizations (ACOs) did not limit spending on discretionary or non-discretionary cardiovascular treatment for patients. ..Read more.
Dartmouth Investigators Push for Substantive Study of Body-Mind Therapy Approaches
February 04, 2015
Dartmouth investigators note the lack of hypothesized scientific models for the mechanisms of action responsible for outcomes in Somatic Experiencing(SE) trauma therapy and other body-mind therapies. ..Read more.
Dartmouth Investigators Develop Groundbreaking Technique to Measure Oxygen in Deep-Sited Tumor an...
February 04, 2015
A novel Electron Paramagnetic Resonance (EPR) oximetry technique will help clinicians directly measure oxygen and schedule treatments at times of high oxygen levels in cancer and stroke patients to improve outcomes, The EPR team at Dartmouth's Geisel School of Medicine has found...Read more.
Dartmouth Researchers Reprogram Tumor's Cells to Attack Itself
February 03, 2015
Inserting a specific strain of bacteria into the microenvironment of aggressive ovarian cancer transforms the behavior of tumor cells from suppression to immunostimulation, researchers at Norris Cotton Cancer Center and the Geisel School of Medicine at Dartmouth have found...Read more.
Dartmouth Cancer Investigators Help National Cancer Institute Present Statistics in More Understa...
February 03, 2015
Three papers in the survival monograph published by the Journal of the National Cancer Institute, co-authored by Dartmouth's Norris Cotton Cancer Center investigators Steven Woloshin, MD, MS, and Lisa Schwartz, MD, MS, aim to help doctors, patients, and policymakers better understand cancer prognosis and survival...Read more.
Dartmouth Researchers Discover New Mechanism of Acquired Resistance to Breast Cancer Drugs
February 02, 2015
In the search for new approaches to treat ERBB2 positive breast cancers that have become drug-resistant, Dartmouth investigator Manabu Kurokawa, PhD, led a team in discovery of a novel cancer resistance mechanism...Read more.
Dartmouth Investigators Conduct Systematic Testing of Deimmunized Biotherapeutic Agents
January 28, 2015
By establishing protein design algorithms that simultaneously optimize drug candidates for both decreased immunogenic epitope content and high level stability and activity, researchers have established a novel testing platform..Read more.
Cherenkov Emissions Provide Dartmouth Investigators Real-Time Tool for Quality Assurance in Radia...
January 23, 2015
Using a simple camera and water tank, investigators demonstrated that induced Cherenkov light can be imaged and used to confirm that the complex spatial dose distribution imparted in dynamic treatment plans is being delivered correctly...Read more.
Noisy Data Facilitates Dartmouth Researcher's Investigation of Breast Cancer Gene Expression
January 22, 2015
Researchers report on the use of denoising autoencoders (DAs) to effectively extract key biological principles from gene expression data and summarize them into constructed features with convenient properties...Read more.
Research Led by Dartmouth Finds Eribulin Effective in Metastatic Breast Cancer
January 21, 2015
While not superior to capecitabine, eribulin is an active and well-tolerated therapy in women with metastatic breast cancer (MBC) receiving this therapy as a first, second, or third line chemotherapy regimen..Read more.
TV Alcohol Ads Associated with Drinking Behavior in Young People
January 19, 2015
Alcohol advertising on television is associated with drinking behavior in youth according to a study by researchers at NCCC and CHaD...Read more.
Electronic Medical Record Provides Dartmouth-Hitchcock Pathologists Powerful Tool to Push Best Pr...
January 15, 2015
By implementing a "best practice alert" function in the electronic medical record, pathologists at Dartmouth-Hitchcock significantly reduced physicians' orders for two-unit transfusions for non-bleeding patients..Read more.
Dartmouth CAR Cell Therapy Moves to Clinical Trial
January 14, 2015
Cancer fighting chimeric antigen receptor (CAR) T cells are taking the next step into a Phase I clinical trial beginning early in 2015...Read more.
Community-Wide Cardiovascular Disease Prevention Programs Associated with Reductions in Hospitali...
January 13, 2015
In a rural Maine county, sustained, community-wide programs targeting cardiovascular risk factors and behavior changes were associated with reductions in hospitalization and death rates over a 40-year period (1970-2010) compared with the rest of the state...Read more.
In Head and Neck Cancer, Surgeons Need Solid Answers About Tumor Recurrence
January 08, 2015
Pathologists at Dartmouth Hitchcock Medical Center's Norris Cotton Cancer Center developed a new use for an old test to determine if a patient's cancer is recurring, or if the biopsy shows benign inflammation of mucosal tissues...Read more.
Dartmouth Develops Prognostic Test for E2F4 in Breast Cancer That Will Be Valuable in Other Cance...
January 07, 2015
By looking at the expression levels of downstream genes of the regulators in breast cancer, Dartmouth investigators, have identified a gene signature in E2F4 that is predictive of estrogen receptor positive (ER+) breast cancer...Read more.