Fast Food Commercials to Kids 'Deceptive' by Industry Self-Regulation Standards
March 05, 2015
Fast food ads aimed at kids fail to de-emphasize toy premiums, and fail to emphasize healthy menu items, investigators at Dartmouth-Hitchcock's Norris Cotton Cancer Center have found...Read more.
U.S. Spends More on Cancer Care, Saves Fewer Lives than Western Europe
March 02, 2015
Such findings have raised questions about the additional value of U.S. cancer care derived from the additional spending, in comparison to the situation in other high-income countries...Read more.
Cherenkov Effect Improves Radiation Therapy for Patients with Cancer
February 25, 2015
The complex parts of the blue light known as the Cherenkov Effect can be measured and used in dosimetry to make therapies safer and more effective. ..Read more.
Dartmouth Investigators Discover Key Indicator for Successful Treatment of Infertile Couples
February 20, 2015
Study determines if follicle stimulating hormone and estrogen at the upper limits of normal could predict treatment success as measured in live birth rates. ..Read more.
Structure-based Design Used as Tool for Engineering Deimmunized Biotherapeutics
February 13, 2015
While methods for identifying immunogenic hotspots, or epitopes, are evolving rapidly, technologies to redesign the hotspots while maintaining biotherapeutic activity and stability are far less developed...Read more.
Google-style Ranking Used to Describe Gene Connectivity
February 13, 2015
Using the technique known as "Gene Rank" (GR), Eugene Demidenko, PhD, captured a new characterization of gene connectivity by using a computer algorithm to compare tissues across or within organisms at great speed with a simple laptop computer...Read more.
Investigators at Dartmouth Identify Key Pathways Underlying Different Subsets of Systemic Scleros...
February 10, 2015
Sorting out patients with systemic sclerosis (SSc) according to their shared biology, researchers discovered how disease heterogeneity can be defined, allowing for targeted selection of patients for clinical trials...Read more.
Dartmouth Physician-Scientists Examine Efficacy of Radiation Therapy in 'Good-Risk' DCIS Patients...
February 09, 2015
A collaborative national clinical trials group discovered that radiation therapy in addition to chemotherapy was even more effective at preventing recurrence of ductal carcinoma in situ (DCIS) than previously thought...Read more.
Dartmouth Investigators Push for Substantive Study of Body-Mind Therapy Approaches
February 04, 2015
Dartmouth investigators note the lack of hypothesized scientific models for the mechanisms of action responsible for outcomes in Somatic Experiencing(SE) trauma therapy and other body-mind therapies. ..Read more.
Dartmouth Investigators Develop Groundbreaking Technique to Measure Oxygen in Deep-Sited Tumor an...
February 04, 2015
A novel Electron Paramagnetic Resonance (EPR) oximetry technique will help clinicians directly measure oxygen and schedule treatments at times of high oxygen levels in cancer and stroke patients to improve outcomes, The EPR team at Dartmouth's Geisel School of Medicine has found...Read more.
Dartmouth Researchers Reprogram Tumor's Cells to Attack Itself
February 03, 2015
Inserting a specific strain of bacteria into the microenvironment of aggressive ovarian cancer transforms the behavior of tumor cells from suppression to immunostimulation, researchers at Norris Cotton Cancer Center and the Geisel School of Medicine at Dartmouth have found...Read more.
Dartmouth Cancer Investigators Help National Cancer Institute Present Statistics in More Understa...
February 03, 2015
Three papers in the survival monograph published by the Journal of the National Cancer Institute, co-authored by Dartmouth's Norris Cotton Cancer Center investigators Steven Woloshin, MD, MS, and Lisa Schwartz, MD, MS, aim to help doctors, patients, and policymakers better understand cancer prognosis and survival...Read more.
Dartmouth Researchers Discover New Mechanism of Acquired Resistance to Breast Cancer Drugs
February 02, 2015
In the search for new approaches to treat ERBB2 positive breast cancers that have become drug-resistant, Dartmouth investigator Manabu Kurokawa, PhD, led a team in discovery of a novel cancer resistance mechanism...Read more.
Dartmouth Investigators Conduct Systematic Testing of Deimmunized Biotherapeutic Agents
January 28, 2015
By establishing protein design algorithms that simultaneously optimize drug candidates for both decreased immunogenic epitope content and high level stability and activity, researchers have established a novel testing platform..Read more.
Cherenkov Emissions Provide Dartmouth Investigators Real-Time Tool for Quality Assurance in Radia...
January 23, 2015
Using a simple camera and water tank, investigators demonstrated that induced Cherenkov light can be imaged and used to confirm that the complex spatial dose distribution imparted in dynamic treatment plans is being delivered correctly...Read more.
Noisy Data Facilitates Dartmouth Researcher's Investigation of Breast Cancer Gene Expression
January 22, 2015
Researchers report on the use of denoising autoencoders (DAs) to effectively extract key biological principles from gene expression data and summarize them into constructed features with convenient properties...Read more.
Research Led by Dartmouth Finds Eribulin Effective in Metastatic Breast Cancer
January 21, 2015
While not superior to capecitabine, eribulin is an active and well-tolerated therapy in women with metastatic breast cancer (MBC) receiving this therapy as a first, second, or third line chemotherapy regimen..Read more.
TV Alcohol Ads Associated with Drinking Behavior in Young People
January 19, 2015
Alcohol advertising on television is associated with drinking behavior in youth according to a study by researchers at NCCC and CHaD...Read more.
Electronic Medical Record Provides Dartmouth-Hitchcock Pathologists Powerful Tool to Push Best Pr...
January 15, 2015
By implementing a "best practice alert" function in the electronic medical record, pathologists at Dartmouth-Hitchcock significantly reduced physicians' orders for two-unit transfusions for non-bleeding patients..Read more.
Dartmouth CAR Cell Therapy Moves to Clinical Trial
January 14, 2015
Cancer fighting chimeric antigen receptor (CAR) T cells are taking the next step into a Phase I clinical trial beginning early in 2015...Read more.
Community-Wide Cardiovascular Disease Prevention Programs Associated with Reductions in Hospitali...
January 13, 2015
In a rural Maine county, sustained, community-wide programs targeting cardiovascular risk factors and behavior changes were associated with reductions in hospitalization and death rates over a 40-year period (1970-2010) compared with the rest of the state...Read more.
In Head and Neck Cancer, Surgeons Need Solid Answers About Tumor Recurrence
January 08, 2015
Pathologists at Dartmouth Hitchcock Medical Center's Norris Cotton Cancer Center developed a new use for an old test to determine if a patient's cancer is recurring, or if the biopsy shows benign inflammation of mucosal tissues...Read more.
Dartmouth Develops Prognostic Test for E2F4 in Breast Cancer That Will Be Valuable in Other Cance...
January 07, 2015
By looking at the expression levels of downstream genes of the regulators in breast cancer, Dartmouth investigators, have identified a gene signature in E2F4 that is predictive of estrogen receptor positive (ER+) breast cancer...Read more.
Dartmouth Researchers Develop Mouse Cell Line to Fast-Track Research in BRAF Melanoma
January 06, 2015
By developing cell lines that grow readily in culture, investigators have created a fast-track research tool that remains applicable to many scientists who use mouse melanoma as a model system. ..Read more.
E-Cigarettes May Recruit Lower Risk Teens to Nicotine Use
December 15, 2014
Researchers at the Norris Cotton Cancer Center and University of Hawaii Cancer Center find that one-third of Hawaiian adolescents have tried e-cigarettes, half of whom have never used another tobacco product...Read more.
Cancer Therapy Using Specialized Apheresis Holds Great Promise
December 11, 2014
Apheresis, the simple process of drawing blood, becomes a powerful therapeutic in extracorporeal photopherisis (ECP) according to clinicians and scientists who met at the NIH State of the Science Symposium in Therapeutic Apheresis...Read more.
Low Income Kids Eat More Fruits and Vegetables When They are in School
December 11, 2014
The fruits and vegetables provided at school deliver an important dietary boost to low income adolescents, according to Meghan Longacre, PhD and Madeline Dalton, PhD of Dartmouth Hitchcock's Norris Cotton Cancer Center and The Hood Center for Children and Families...Read more.
Women with Dense Breasts Will Have to Look Beyond Ultrasound for Useful Supplemental Breast Cance...
December 09, 2014
Supplemental ultrasound screening for all U.S. women with dense breasts would substantially increase healthcare costs with little improvement in overall health, according to senior author Anna Tosteson, ScD, at Dartmouth Hitchcock's Norris Cotton Cancer Center and The Dartmouth Institute for Health Policy and Clinical Practice. ..Read more.
Hookah Smoking Increases Risk of Subsequent Cigarette Smoking Among Adolescents and Young Adults
December 08, 2014
A team of researchers at Dartmouth College and University of Pittsburgh found respondents who had smoked water pipe tobacco but not smoked cigarettes were at increased risk of cigarette smoking two years later as recently published online in JAMA Pediatrics. ..Read more.
New Imaging Technique Identifies Receptors for Targeted Cancer Therapy
November 14, 2014
Dartmouth researchers have developed a fluorescence imaging technique that can more accurately identify receptors for targeted cancer therapies without a tissue biopsy. ..Read more.
Lung Cancer Screening with Low-Dose CT Could Be Cost Effective According to Dartmouth Study
November 10, 2014
This relatively new screening test uses annual low-dose CT scans to spot lung tumors early in individuals facing the highest risks of lung cancer due to age and smoking history...Read more.
Dartmouth Researchers Help Develop Better, Safer Way to Detect Cancer in Lymph Nodes
October 27, 2014
The team presents a new and improved method of noninvasive molecular imaging using a "dual-tracer" technique that corrects the problem of nonspecific uptake of imaging tracers that has made previous attempts at this approach clinically ineffective...Read more.
Dartmouth Study Measures Breast Cancer Tumor Response to Neoadjuvant Chemotherapy
October 23, 2014
A Dartmouth study suggests that it may be possible to use Diffuse Optical Spectroscopic Tomographic imaging (DOST) to predict which patients will best respond to chemotherapy used to shrink breast cancer tumors before surgery...Read more.
Dartmouth Researchers Develop Reproducibility Score for SNPs Associated with Human Disease in GWA...
October 08, 2014
To reduce false positives when identifying genetic variations associated with human disease through genome-wide association studies (GWAS), Dartmouth researchers have identified nine traits that are not dependent on P values to predict single nucleotide polymorphisms (SNP) reproducibility as reported in Human Genetics on October 2, 2014...Read more.
Melanoma Risk Found to Have Genetic Determinant
September 18, 2014
A leading Dartmouth researcher, working with The Melanoma Genetics Consortium, GenoMEL, an international research consortium, co-authored a paper published today in the Journal of the National Cancer Institute that proves longer telomeres increase the risk of melanoma...Read more.
Dartmouth Research Links Genetic Mutation and Melanoma Progression
September 11, 2014
Dartmouth researchers find that the genetic mutation BRAFV600E not only secretes a protein that promotes the growth of melanoma tumor cells, but can also modify the network of normal cells around the tumor to support the disease's progression. ..Read more.
African American Women Receive Less Breast Reconstruction after Mastectomy
September 09, 2014
Dartmouth researchers have found that African American women are 55 percent less likely to receive breast reconstruction after mastectomy regardless of where they received their care. ..Read more.
Bone Cancer Surgical Team Sees Success in New Application of Surgical Aid
September 08, 2014
An ortho-oncology team at Dartmouth-Hitchcock Norris Cotton Cancer Center successfully adapted a shoulder surgical aid (the Spider Limb Positioner) to conduct a left hip disarticulation on a melanoma patient...Read more.