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Norris Cotton Cancer CenterNorris Cotton Cancer Center
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Gastrointestinal Oncology Program Clinical Trials

A clinical trial is one of the final steps in a long and careful cancer research process that is looking for better ways to prevent, diagnose, or treat cancer. Clinical trials test new medical approaches in patients with cancer, and are important to developing new treatments for cancer. Many of the "standard treatments" that patients with cancer receive today were developed based on the results of previous clinical trials.

The following is a list of clinical trials with which this cancer care program is currently involved. Talk to your doctor to find out if a clinical trial is right for you.

Colon Clinical Trials
A Phase II Basket Study of the Oral TRK Inhibitor LOXO-101 in Subjects with NTRK Fusion-Positive Tumors
Colon
F16078
Chamberlin
A Phase III Study of the Impact of a Physical Activity Program on Disease-Free Survival in Patients With High Risk Stage II or Stage III Colon Cancer: A Randomized Controlled Trial (CHALLENGE)
Colon
CO.21
Chamberlin
A Randomized Phase II Study of Irinotecan and Cetuximab with or without the Anti-Angiogenic Antibody, Ramucirumab (IMC-1121B), in Advanced K-ras Wild-Type Colorectal Cancer Following Progression on Bevacizumab-Containing Chemotherapy.
Colon
E7208
Hourdequin
Randomized Phase II Study of Cisplatin and Etoposide versus Temozolomide and Capecitabine in Patients with Advanced G3 Non-Small Cell Gastroenteropancreatic Neuroendocrine Carcinomas
Colon
EA2142
Hourdequin
Randomized Phase II Study of Irinotecan and Cetuximab with or without Vemurafenib in BRAF Mutant Metastatic Colorectal Cancer
Colon
S1406
Hourdequin
Esophagus Clinical Trials
Feasibility of a Creative Writing Intervention in an Advanced Cancer Population: A Single Arm, Cohort Study
Esophagus
D15113
Vergo
Randomized Phase II Study of Cisplatin and Etoposide versus Temozolomide and Capecitabine in Patients with Advanced G3 Non-Small Cell Gastroenteropancreatic Neuroendocrine Carcinomas
Esophagus
EA2142
Hourdequin
Randomized Study of Early Palliative Care Integrated with Standard Oncology Care versus Standard Oncology Care Alone in Patients with Incurable Lung or Non-Colorectal Gastrointestinal Malignancies
Esophagus
A221303
Cullinan
Liver Clinical Trials
Feasibility of a Creative Writing Intervention in an Advanced Cancer Population: A Single Arm, Cohort Study
Liver
D15113
Vergo
Randomized Study of Early Palliative Care Integrated with Standard Oncology Care versus Standard Oncology Care Alone in Patients with Incurable Lung or Non-Colorectal Gastrointestinal Malignancies
Liver
A221303
Cullinan
Treatment of Children with All Stages of Hepatoblastoma with Temsirolimus (IND#122782, NSC#683864) Added to High Risk Stratum Treatment
Liver
AHEP0731
Chaffee
Other Digestive Organ Clinical Trials
A Phase II Basket Study of the Oral TRK Inhibitor LOXO-101 in Subjects with NTRK Fusion-Positive Tumors
Other Digestive Organ
F16078
Chamberlin
Feasibility of a Creative Writing Intervention in an Advanced Cancer Population: A Single Arm, Cohort Study
Other Digestive Organ
D15113
Vergo
Randomized Study of Early Palliative Care Integrated with Standard Oncology Care versus Standard Oncology Care Alone in Patients with Incurable Lung or Non-Colorectal Gastrointestinal Malignancies
Other Digestive Organ
A221303
Cullinan
Pancreas Clinical Trials
Feasibility of a Creative Writing Intervention in an Advanced Cancer Population: A Single Arm, Cohort Study
Pancreas
D15113
Vergo
Randomized Phase II Study of Cisplatin and Etoposide versus Temozolomide and Capecitabine in Patients with Advanced G3 Non-Small Cell Gastroenteropancreatic Neuroendocrine Carcinomas
Pancreas
EA2142
Hourdequin
Randomized Study of Early Palliative Care Integrated with Standard Oncology Care versus Standard Oncology Care Alone in Patients with Incurable Lung or Non-Colorectal Gastrointestinal Malignancies
Pancreas
A221303
Cullinan
Rectum Clinical Trials
A Phase II Basket Study of the Oral TRK Inhibitor LOXO-101 in Subjects with NTRK Fusion-Positive Tumors
Rectum
F16078
Chamberlin
A Phase II/III trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision
Rectum
N1048
Holubar
A Randomized Phase II Study of Irinotecan and Cetuximab with or without the Anti-Angiogenic Antibody, Ramucirumab (IMC-1121B), in Advanced K-ras Wild-Type Colorectal Cancer Following Progression on Bevacizumab-Containing Chemotherapy.
Rectum
E7208
Hourdequin
Randomized Phase II Study of Cisplatin and Etoposide versus Temozolomide and Capecitabine in Patients with Advanced G3 Non-Small Cell Gastroenteropancreatic Neuroendocrine Carcinomas
Rectum
EA2142
Hourdequin
Randomized Phase II Study of Irinotecan and Cetuximab with or without Vemurafenib in BRAF Mutant Metastatic Colorectal Cancer
Rectum
S1406
Hourdequin
Small Intestine Clinical Trials
Feasibility of a Creative Writing Intervention in an Advanced Cancer Population: A Single Arm, Cohort Study
Small Intestine
D15113
Vergo
Randomized Phase II Study of Cisplatin and Etoposide versus Temozolomide and Capecitabine in Patients with Advanced G3 Non-Small Cell Gastroenteropancreatic Neuroendocrine Carcinomas
Small Intestine
EA2142
Hourdequin
Stomach Clinical Trials
Feasibility of a Creative Writing Intervention in an Advanced Cancer Population: A Single Arm, Cohort Study
Stomach
D15113
Vergo
Randomized Study of Early Palliative Care Integrated with Standard Oncology Care versus Standard Oncology Care Alone in Patients with Incurable Lung or Non-Colorectal Gastrointestinal Malignancies
Stomach
A221303
Cullinan
Randomized, Double-Blind, Phase 3 Study Evaluating TAS-102 Plus Best Supportive Care (BSC) Versus Placebo Plus BSC In Patients With Metastatic Gastric Cancer Refractory to Standard Treatments
Stomach
F16091
Hourdequin

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