Cancer Care

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Neuro-Oncology Program Clinical Trials

A clinical trial is one of the final steps in a long and careful cancer research process that is looking for better ways to prevent, diagnose, or treat cancer. Clinical trials test new medical approaches in patients with cancer, and are important to developing new treatments for cancer. Many of the "standard treatments" that patients with cancer receive today were developed based on the results of previous clinical trials.

The following is a list of clinical trials with which this cancer care program is currently involved. Talk to your doctor to find out if a clinical trial is right for you.

Brain and Nervous System Clinical Trials
A Children's Oncology Group Protocol for Collecting and Banking Brain Tumor Research Specimens
Brain and Nervous System
ACNS02B3
Chaffee
A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas
Brain and Nervous System
ACNS1022
Chaffee
A Phase III Randomized, Double-Blind Placebo Controlled Study of Armodafinil (Nuvigil) To Reduce Cancer-Related Fatigue in Patients with High Grade Glioma
Brain and Nervous System
A221101
Ronan
A Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial.
Brain and Nervous System
R0834
Hartford
A Pilot Study of the Utility of Magnetic Resonance Elastography Study of Brain Tumors
Brain and Nervous System
D14081
Ronan
A Proof-of-Principle Study of Hyperbaric Oxygen as a Radiosensitizer Prior to Stereotactic Radiosurgery for Brain Metastases
Brain and Nervous System
D12129
Hartford
A071102 - A Phase II/III Randomized Trial Of Veliparib Or Placebo In Combination With Adjuvant Temozolomide In Newly Diagnosed Glioblastoma With MGMT Promoter Hypermethylation
Brain and Nervous System
A071102
Ronan
ACNS0821 Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus Bevacizumab (NSC# 704865, BB-IND# 7921) for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial
Brain and Nervous System
ACNS0821
Chaffee
ACNS1123 Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT)
Brain and Nervous System
ACNS1123
Chaffee
Coagulation activation in brain neoplasms
Brain and Nervous System
D12096
Ornstein
Efficacy of Carboplatin Administered Concomitantly with Isotretinoin as a Pro-Apoptotic Agent in Other than Average Risk Medulloblastoma/PNET Patients
Brain and Nervous System
ACNS0332
Chaffee
Evaluating the Expression Levels of MicroRNA-10b in Patients with Gliomas
Brain and Nervous System
D12160
Gaur
Immunologic Evaluation of Peripheral Blood
Brain and Nervous System
D0229
Fadul
Neuroblastoma Biology Studies
Brain and Nervous System
ANBL00B1
Chaffee
Phase II Randomized Study Of Rituximab, Methotrexate, Procarbazine, Vincristine, And Cytarabine With And Without Low-Dose Whole-Brain Radiotherapy For Primary Central Nervous System Lymphoma
Brain and Nervous System
R1114
Hartford
Phase II Trial Of Observation For Low-Risk Meningiomas And Of Radiotherapy For Intermediate and High-Risk Meningiomas
Brain and Nervous System
R0539
Hartford
Phase III Intergroup Study of Radiotherapy with Concomitant and Adjuvant Temozolomide versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients with 1p/19q Co-deleted Anaplastic Glioma or Low Grade Glioma
Brain and Nervous System
N0577
Ronan
Pilot Study to Develop Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Carcinomatosis in Patients with Metastatic Solid Tumor Cancer
Brain and Nervous System
D13237
Ronan
Quantification of ALA-induced PpIX Fluorescence During Brain Tumor Resection
Brain and Nervous System
D13066
Roberts
Randomized Phase II Study of Irinotecan and Cetuximab with or without Vemurafenib in BRAF Mutant Metastatic Colorectal Cancer
Brain and Nervous System
S1406
Hourdequin
Randomized Phase Ii Trial Of Hypofractionated Dose-Escalated Photon Imrt Or Proton Beam Therapy Versus Conventional Photon Irradiation With Concomitant And Adjuvant Temozolomide In Patients With Newly Diagnosed Glioblastoma
Brain and Nervous System
NRG-BN001
Reducing Disparities in Health for Vulnerable Populations in NH and VT: Journey Forward Cancer Survivor Care Planning in the Rural Northeast
Brain and Nervous System
FED11061
Pace
Umbrella Long-Term Follow Up Protocol
Brain and Nervous System
ALTE05N1
Chaffee