Cancer Care

 

 

Neuro-Oncology Program Clinical Trials

A clinical trial is one of the final steps in a long and careful cancer research process that is looking for better ways to prevent, diagnose, or treat cancer. Clinical trials test new medical approaches in patients with cancer, and are important to developing new treatments for cancer. Many of the "standard treatments" that patients with cancer receive today were developed based on the results of previous clinical trials.

The following is a list of clinical trials with which this cancer care program is currently involved. Talk to your doctor to find out if a clinical trial is right for you.

Brain and Nervous System Clinical Trials
A Children's Oncology Group Protocol for Collecting and Banking Brain Tumor Research Specimens
Brain and Nervous System
ACNS02B3
Chaffee
A Phase II, Open-Label, Multi-Center Study of ANG1005 in Patients with Recurrent High-Grade Glioma
Brain and Nervous System
F14138
Fadul
A Phase III Randomized Study of Chimeric Anti-GD2 in High Risk Neuroblastoma following Myeloablative Therapy and Autologous Stem Cell Transplant (Companion Study to A3973)
Brain and Nervous System
ANBL0032
Chaffee
A Phase III Randomized, Double-Blind Placebo Controlled Study of Armodafinil (Nuvigil®) To Reduce Cancer-Related Fatigue in Patients with High Grade Glioma
Brain and Nervous System
A221101
Fadul
A Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial.
Brain and Nervous System
R0834
Hartford
A proof-of-principle study of hyperbaric oxygen as a radiosensitizer prior to sterotactic radiosurgery for brain metastases
Brain and Nervous System
D12129
Hartford
ACNS0821 Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus Bevacizumab (NSC# 704865, BB-IND# 7921) for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial
Brain and Nervous System
ACNS0821
Chaffee
ACNS1123 Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT)
Brain and Nervous System
ACNS1123
Chaffee
An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF with Adjuvant Temozolomide in Patients with Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma (The “ACT IV” Study)
Brain and Nervous System
F12019
Fadul
Coagulation activation in brain neoplasms
Brain and Nervous System
D12096
Ornstein
Decision Support for Patients with Malignant Glioma: Needs Assessment Survey
Brain and Nervous System
D13166
Ronan
Efficacy of Carboplatin Administered Concomitantly with Isotretinoin as a Pro-Apoptotic Agent in Other than Average Risk Medulloblastoma/PNET Patients
Brain and Nervous System
ACNS0332
Chaffee
Evaluating the Expression Levels of MicroRNA-10b in Patients with Gliomas
Brain and Nervous System
D12160
Gaur
Immunologic Evaluation of Peripheral Blood
Brain and Nervous System
D0229
Fadul
Neuroblastoma Biology Studies
Brain and Nervous System
ANBL00B1
Chaffee
Phase I/Comparative Randomized Phase II Trial of TRC105 plus Bevacizumab versus Bevacizumab in Bevacizumab-Naïve Patients with Recurrent Glioblastoma Multiforme
Brain and Nervous System
N1174
Fadul
Phase II Randomized Study Of Rituximab, Methotrexate, Procarbazine, Vincristine, And Cytarabine With And Without Low-Dose Whole-Brain Radiotherapy For Primary Central Nervous System Lymphoma
Brain and Nervous System
R1114
Hartford
Phase II Trial Of Observation For Low-Risk Meningiomas And Of Radiotherapy For Intermediate and High-Risk Meningiomas
Brain and Nervous System
R0539
Hartford
Phase III Intergroup Study Of Temozolomide Alone Versus Radiotherapy With Concomitant And Adjuvant Temozolomide versus Radiotherapy with Adjuvant PCV Chemotherapy in Patients With 1p/19q Co-deleted Anaplastic Glioma
Brain and Nervous System
N0577
Fadul
Pilot Study to Develop Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Carcinomatosis in Patients with Metastatic Solid Tumor Cancer
Brain and Nervous System
D13237
Ronan
Protocol for Use of Brain Tumor Tissue for Research
Brain and Nervous System
D0004
Fadul
Quantification of ALA-induced PpIX Fluorescence During Brain Tumor Resection
Brain and Nervous System
D13066
Roberts
RTOG 0925: Natural History of Postoperative Cognitive Function, Quality of Life, and Seizure Control in Patients with Supratentorial Low-Risk Grade II Glioma
Brain and Nervous System
R0925
Hartford
Reducing Disparities in Health for Vulnerable Populations in NH and VT: Journey Forward Cancer Survivor Care Planning in the Rural Northeast
Brain and Nervous System
FED11061
Pace
Umbrella Long-Term Follow Up Protocol
Brain and Nervous System
ALTE05N1
Chaffee
Vaccination of Patients with Newly Diagnosed Glioblastoma Using Autologous Tumor Lysate and Montanide Emulsion for Derivation of Tumor Specific Hybridomas
Brain and Nervous System
W12209
Fadul