IBCSG-24-02: A Phase III Trial Evaluating the Role of Ovarian Function Suppression and the Role of Exemestane as Adjuvant Therapies for Premenopausal Women with Endocrine Responsive Breast Cancer (SOFT)
RATIONALE: Estrogen can stimulate the growth of breast tumor cells. Ovarian function
suppression combined with hormone therapy using tamoxifen or exemestane may fight breast
cancer by reducing the production of estrogen. It is not yet known whether suppression of
ovarian function plus either tamoxifen or exemestane is more effective than tamoxifen alone
in preventing the recurrence of hormone-responsive breast cancer.
PURPOSE: This randomized phase III trial studies ovarian suppression with either tamoxifen
or exemestane to see how well they work compared to tamoxifen alone in treating
premenopausal women who have undergone surgery for hormone-responsive breast cancer.
View more details from ClinicalTrials.gov.
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