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Biomarkers In Chemotherapy-Induced Peripheral Neurotoxicity: Better Tools And Understanding
Principal Investigator (?)
Study Number
D17062
Summary
This pilot study will attempt to establish the feasibility of using tissue oxygen measurements as a potential biomarker for chemotherapy-induced peripheral neuropathy (CIPN). Thirty (30) subjects scheduled to begin taxane-based chemotherapy for breast tumor will be assigned to receive an India ink injection under the skin of the foot. The ink will be used to make up to five (5) 45-minute "electron paramagnetic resonance" (EPR) oximetry readings prior to the start of chemotherapy. Subjects will undergo electrophysiologic assessments including electromyography and nerve conduction studies, in addition to a neurological examination prior to the start of chemotherapy. Subjects will have the EPR oximetry readings, electrophysiologic tests, and neurological examination two more times: at the halfway point of their chemotherapy treatment -- or at the onset of CIPN symptoms -- and again after chemotherapy has been completed. 
Phase (?)
Phase III
Available at the following location(s)

Lebanon

View more details from ClinicalTrials.gov.

Contact Information

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