chemotherapy, such as vincristine, cisplatin, lomustine, and cyclophosphamide, work in
different ways to stop tumor cells from dividing so they stop growing or die. Giving
radiation therapy with chemotherapy after surgery may kill any remaining tumor cells. It is
not yet known whether standard-dose radiation therapy combined with chemotherapy after
surgery is more effective than reduced-dose craniospinal (head and spine) radiation therapy
plus either posterior fossa (back of the brain) boost or tumor bed (site of the tumor) boost
radiation therapy combined with chemotherapy in treating medulloblastoma.
PURPOSE: This randomized phase III trial is studying standard-dose radiation therapy to see
how well it works compared to reduced-dose craniospinal radiation therapy AND posterior
fossa boost radiation therapy to see how well it works compared to tumor bed boost radiation
therapy when given together with chemotherapy in treating young patients who have undergone
surgery for newly diagnosed standard-risk medulloblastoma.
For more information about a clinical trial, clinical trial eligibility, or informed consent, contact our research nurses by phone or email:
- Cancer Help Line: (800) 639-6918
- Email: email@example.com
Please Note: Any eligibility criteria noted are subject to change. Our research nurses can provide you with the most current eligibility and exclusion criteria. Any study involvement to be undertaken must ultimately be determined on an individual basis.