Efficacy of Carboplatin Administered Concomitantly with Isotretinoin as a Pro-Apoptotic Agent in Other than Average Risk Medulloblastoma/PNET Patients
This randomized phase III trial studies different chemotherapy and radiation therapy
regimens to compare how well they work in treating young patients with newly diagnosed,
previously untreated, high-risk medulloblastoma. Drugs used in chemotherapy, such as
vincristine sulfate, cisplatin, cyclophosphamide, and carboplatin, work in different ways to
stop the growth of tumor cells, either by killing the cells, by stopping them from dividing,
or by stopping them from spreading. Giving more than one drug (combination chemotherapy) may
kill more tumor cells. Isotretinoin may help chemotherapy work better by making tumor cells
more sensitive to the drugs. Radiation therapy uses high-energy x-rays to kill tumor cells.
Carboplatin may make tumor cells more sensitive to radiation therapy. It is not yet known
which chemotherapy and radiation therapy regimen is more effective in treating brain tumors.
View more details from ClinicalTrials.gov.
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