ACNS0821 Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus Bevacizumab (NSC# 704865, BB-IND# 7921) for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG Randomized Phase II Screening Trial
This randomized phase II trial studies how well giving temozolomide and irinotecan
hydrochloride together with or without bevacizumab works in treating young patients with
recurrent or refractory medulloblastoma or central nervous system (CNS) primitive
neuroectodermal tumors. Drugs used in chemotherapy, such as temozolomide and irinotecan
hydrochloride, work in different ways to stop the growth of tumor cells, either by killing
the cells, by stopping them from dividing, or by stopping them from spreading. Monoclonal
antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the
ability of tumor cells to grow and spread. Others find tumor cells and help kill them or
carry tumor-killing substances to them. It is not yet known whether temozolomide and
irinotecan hydrochloride are more effective with or without bevacizumab in treating
medulloblastoma or CNS primitive neuroectodermal tumors.
View more details from ClinicalTrials.gov.
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