A Phase II Randomized Trial of Lenalidomide (NSC # 703813, IND # 70116) in Pediatric Patients with Recurrent, Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas
This randomized phase II trial studies how well low-dose lenalidomide works compared with
high-dose lenalidomide in treating younger patients with juvenile pilocytic astrocytomas or
optic nerve pathway gliomas that have come back (recurrent), have not responded to treatment
(refractory), or are growing, spreading, or getting worse (progressive). Lenalidomide may
stop the growth of tumor cells by blocking blood flow to the tumor. It is not yet known
whether low-dose lenalidomide is more or less effective than high-dose lenalidomide in
treating patients with juvenile pilocytic astrocytomas or optic nerve pathway gliomas.
View more details from ClinicalTrials.gov.
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