Cancer Care

 

 
A Phase III Randomized Study of Chimeric Anti-GD2 in High Risk Neuroblastoma following Myeloablative Therapy and Autologous Stem Cell Transplant (Companion Study to A3973)
Principal Investigator (?)
Study Number
ANBL0032
Summary
This partially randomized phase III trial studies isotretinoin with monoclonal antibody
Ch14.18, aldesleukin, and sargramostim to see how well it works compared to isotretinoin
alone following stem cell transplant in treating patients with neuroblastoma. Drugs used in
chemotherapy, such as isotretinoin, work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies,
such as monoclonal antibody Ch14.18, can block tumor growth in different ways. Some block
the ability of tumors to grow and spread. Others find tumor cells and help kill them or
deliver tumor-killing substances to them. Aldesleukin and sargramostim may stimulate a
person''s white blood cells to kill cancer cells. It is not yet known if chemotherapy is more
effective with or without monoclonal antibody Ch14.18, aldesleukin, and sargramostim
following stem cell transplant in treating neuroblastoma.
Phase (?)
Phase III
Sponsor (?)
Available at the following location(s)

Lebanon

View more details from ClinicalTrials.gov.

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