Phase III Trial of Doxorubicin and Cyclophosphamide (AC) Followed by Weekly Paclitaxel with or without Trastuzumab as Adjuvant Treatment for Women with HER-2 Overexpressing or Amplified Node Positive or High-Risk Node Negative Breast Cancer
This randomized phase III trial studies combination chemotherapy and trastuzumab to see how
well they work compared to combination chemotherapy alone in treating women with breast
cancer. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Monoclonal antibodies such as trastuzumab can locate tumor cells
and either kill them or deliver tumor-killing substances to them without harming normal
cells. It is not yet known whether combination chemotherapy is more effective with or
without trastuzumab in treating breast cancer.
View more details from ClinicalTrials.gov.
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