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sulfamethoxazole and trimethoprim

Pronunciation: SUL fa meth OX a zole and trye METH oh prim

Brand: Bactrim, Bactrim DS, Septra, Septra DS, SMZ-TMP DS, Sulfatrim Pediatric

SMZ-TMP DS-MUT

elliptical, white, imprinted with MP 85

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Sulfamethoxazole-TMP DS-TEV

oblong, white, imprinted with 93 089

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Sulfamethoxazole-TMP SS-TEV

round, white, imprinted with 93 088

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Sulfamethoxazole-Trimethoprim 400 mg-80 mg-URL

round, white, imprinted with MP 81

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Sulfamethoxazole-Trimethoprim 400 mg-80mg-AMN

oval, white, imprinted with IP 271

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Sulfamethoxazole-Trimethoprim DS-AMN

oval, white, imprinted with IP 272

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Sulfamethoxazole-Trimethoprim DS-EON

oval, white, imprinted with E 112

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What is the most important information I should know about sulfamethoxazole and trimethoprim?

Multum donot

You should not use this medication if you are allergic to sulfamethoxazole or trimethoprim, if you are pregnant or breast-feeding, or if you have anemia (lack of red blood cells) caused by folic acid deficiency.

Before using this medication, tell your doctor if you have kidney or liver disease, a folic acid deficiency, asthma or severe allergies, a thyroid disorder, HIV or AIDS, porphyria, G6PD deficiency, or if you are malnourished.

Multum finish

Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Sulfamethoxazole and trimethoprim will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

Multum nosun

Avoid exposure to sunlight or tanning beds. This medication can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What is sulfamethoxazole and trimethoprim?

Sulfamethoxazole and trimethoprim are both antibiotics that treat different types of infection caused by bacteria.

The combination of sulfamethoxazole and trimethoprim is used to treat ear infections, urinary tract infections, bronchitis, traveler's diarrhea, shigellosis, and Pneumocystis jiroveci pneumonia.

Sulfamethoxazole and trimethoprim may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking sulfamethoxazole and trimethoprim?

Multum donot

You should not use this medication if you are allergic to sulfamethoxazole or trimethoprim, if you are pregnant or breast-feeding, or if you have anemia (lack of red blood cells) caused by folic acid deficiency.

To make sure this medication is safe for you, tell your doctor if you have any of these other conditions:

  • kidney or liver disease;
  • a folic acid deficiency;
  • asthma or severe allergies;
  • a thyroid disorder;
  • HIV or AIDS;
  • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
  • a glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency); or
  • if you are malnourished.
Multum nopreg

FDA pregnancy category C. It is not known whether sulfamethoxazole and trimethoprim will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

Sulfamethoxazole and trimethoprim can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Multum nochild

Do not give this medication to a child younger than 2 months old.

Older adults may be more likely to have side effects from this medicine.

How should I take sulfamethoxazole and trimethoprim?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Multum finish

Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Sulfamethoxazole and trimethoprim will not treat a viral infection such as the common cold or flu.

Multum water

Drink plenty of fluids to prevent kidney stones while you are taking trimethoprim and sulfamethoxazole.

Multum emt

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using sulfamethoxazole and trimethoprim.

Multum rt

Store at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

What should I avoid while taking sulfamethoxazole and trimethoprim?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking this medication and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Multum nosun

Avoid exposure to sunlight or tanning beds. This medication can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of sulfamethoxazole and trimethoprim?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have a serious side effect such as:

  • diarrhea that is watery or bloody;
  • fever, chills, swollen glands, body aches, flu symptoms, sores in your mouth and throat;
  • new or worsening cough;
  • pale skin, feeling light-headed, rapid heart rate, trouble concentrating;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • severe tingling or numbness, slow heart rate, weak pulse, muscle weakness;
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • urinating less than usual or not at all;
  • hallucinations, seizure (convulsions);
  • low blood sugar (headache, hunger, weakness, sweating, confusion, irritability, or feeling jittery);
  • the first sign of any skin rash, no matter how mild; or
  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • vomiting;
  • painful or swollen tongue;
  • dizziness, spinning sensation;
  • ringing in your ears; or
  • tired feeling, sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect sulfamethoxazole and trimethoprim?

Tell your doctor about all other medications you use, especially:

  • an antidepressant;
  • a blood thinner such as warfarin (Coumadin, Jantoven);
  • cyclosporine (Gengraf, Neoral, Sandimmune);
  • oral diabetes medication;
  • digoxin (Lanoxin, Lanoxicaps);
  • a diuretic (water pill);
  • indomethacin (Indocin);
  • leucovorin, calcium folinate;
  • methotrexate (Trexall, Rheumatrex);
  • heart or blood pressure medication such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).
  • seizure medication such as phenytoin (Dilantin);

This list is not complete and other drugs may interact with sulfamethoxazole and trimethoprim. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about sulfamethoxazole and trimethoprim.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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