Health Encyclopedia

 

 

imipramine

Pronunciation: im IP ra meen

Brand: Tofranil, Tofranil-PM

Imipramine 10 mg-GG

round, yellow, imprinted with GG, 41

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Imipramine 10 mg-MUT

round, yellow, imprinted with MP 4

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Imipramine 10 mg-PAR

triangular, yellow, imprinted with par, 54

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Imipramine 25 mg-GG

round, beige, imprinted with 47, GG

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Imipramine 25 mg-PAR

round, brown, imprinted with 55, par

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Imipramine 25 mg-URL

round, brown, imprinted with MP 8

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Imipramine 50 mg-GG

round, green, imprinted with GG, 42

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Imipramine 50 mg-MUT

round, green, imprinted with MP 79

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Imipramine 50 mg-PAR

round, green, imprinted with 56, par

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Imipramine Pamoate 100 mg-ROX

capsule, red/yellow, imprinted with 54758

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Imipramine Pamoate 125 mg-ROX

capsule, brown, imprinted with 54466

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Imipramine Pamoate 150 mg-ROX

capsule, brown, imprinted with 54 161

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Imipramine Pamoate 75 mg-ROX

capsule, brown, imprinted with 54591

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Tofranil 25 mg-MAL

round, orange, imprinted with M inside a box, 25

Image of Tofranil 25 mg-MAL
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Tofranil 50 mg-MAL

round, orange, imprinted with 50, M inside a box

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Tofranil 10 mg-MAL

triangular, orange, imprinted with 10, M inside a box

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What is the most important information I should know about imipramine?

Multum donot

You should not take this medicine if you have recently had a heart attack, or if you are allergic to imipramine or similar antidepressants such as amitriptyline, amoxapine, clomipramine, desipramine, doxepin, nortriptyline, protriptyline, or trimipramine.

Do not use imipramine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

What is imipramine?

Imipramine is a tricyclic antidepressant. Imipramine affects chemicals in the brain that may become unbalanced.

Imipramine is used to treat symptoms of depression. Imipramine is sometimes used to treat bed-wetting in children ages 6 and older.

Imipramine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking imipramine?

Multum donot

You should not take this medicine if you have recently had a heart attack, or if you are allergic to imipramine or similar antidepressants such as amitriptyline, amoxapine, clomipramine, desipramine, doxepin, nortriptyline, protriptyline, or trimipramine.

Do not use imipramine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

To make sure imipramine is safe for you, tell your doctor if you have:

  • heart disease, a history of heart attack, stroke, or seizures;
  • bipolar disorder (manic-depression);
  • kidney or liver disease;
  • overactive thyroid, adrenal gland tumor (pheochromocytoma);
  • diabetes (imipramine may raise or lower blood sugar);
  • glaucoma;
  • problems with urination; or
  • if you are being treated with methylene blue injection.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using imipramine. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Multum nopreg

FDA pregnancy category C. It is not known whether imipramine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

Imipramine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Multum nochild

Do not give this medicine to a child without medical advice.

How should I take imipramine?

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

If you need surgery, tell the surgeon ahead of time that you are using imipramine. You may need to stop using the medicine for a short time.

It may take up to 3 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

Multum donot

Do not stop using imipramine without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Multum rt

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of imipramine can be fatal.

What should I avoid while taking imipramine?

Multum noalcohol

Avoid drinking alcohol. It can cause dangerous side effects when taken together with imipramine.

Grapefruit and grapefruit juice may interact with imipramine. Discuss the use of grapefruit products with your doctor before increasing or decreasing the amount of grapefruit products in your diet.

Multum dizzy

Imipramine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Multum nosun

Avoid exposure to sunlight or tanning beds. Imipramine can make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

What are the possible side effects of imipramine?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Multum calldoc

Call your doctor at once if you have:

  • feeling like you might pass out;
  • new or worsening chest pain, pounding heartbeats or fluttering in your chest;
  • sudden numbness or weakness, problems with vision, speech, or balance;
  • fever, sore throat;
  • easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
  • confusion, hallucinations, unusual thoughts or behavior;
  • painful or difficult urination;
  • seizure (convulsions); or
  • jaundice (yellowing of the skin or eyes).

Other common side effects may include:

  • tingly feeling, weakness, lack of coordination;
  • dry mouth, nausea, vomiting, constipation, diarrhea;
  • blurred vision, ringing in your ears;
  • breast swelling (in men or women); or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect imipramine?

Multum dizzy

Taking imipramine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking imipramine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Before taking imipramine, tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, or sertraline.

You must wait at least 5 weeks after stopping fluoxetine (Prozac) before you can take imipramine.

Many drugs can interact with imipramine. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with imipramine, especially:

  • bupropion;
  • cimetidine;
  • clonidine;
  • methylphenidate, Ritalin;
  • phenobarbital and other barbiturates;
  • phenytoin;
  • quinidine;
  • St. John's wort;
  • terbinafine;
  • any other anti-depressant, or medication to treat mental illness;
  • bladder or urinary medicines such as darifenacin, tolterodine, solifenacin;
  • bronchodilators such as ipratropium or tiotropium;
  • cold or allergy medicine that contains an antihistamine;
  • the heart rhythm medications flecainide, propafenone, or quinidine;
  • medication for Parkinson's disease; or
  • medication to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome.

This list is not complete and many other drugs can interact with imipramine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Where can I get more information?

Your pharmacist can provide more information about imipramine.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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