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nitroglycerin (rectal)

Pronunciation: NYE troe GLIS er in

Brand: Rectiv

What is the most important information I should know about nitroglycerin rectal?

Multum donot

You should not use this medication if you are allergic to nitroglycerin or any other nitrate medication. This includes isosorbide dinitrate (Dilatrate, Isordil, Isochron), isosorbide mononitrate (Imdur, ISMO, Monoket), or nitroglycerin used in a pill form or spray under the tongue, or as a skin patch or ointment (Minitran, Nitrek, Nitro-Bid, Nitro-Dur, Nitrolingual, Nitromist, Nitrostat, Nitro-Time, and others.)

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Do not use nitroglycerin rectal if you are taking sildenafil (Viagra, Revatio), avanafil (Stendra), tadalafil (Cialis), or vardenafil (Levitra). Serious, life-threatening side effects can occur if you use nitroglycerin rectal while you are using sildenafil.

Multum donot

You also should not use nitroglycerin rectal if you have: severe anemia (a lack of red blood cells), or a brain injury, hemorrhage, or tumor.

Before using nitroglycerin rectal, tell your doctor if you have congestive heart failure, low blood pressure, glaucoma, liver disease, migraine headaches, or a history of heart attack, stroke, or circulation problems.

Do not use this medication without the advice of a doctor if you have early signs of a heart attack (chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling). Seek emergency medical attention if you have symptoms of a heart attack.

Nitroglycerin rectal can cause severe headaches, which may occur each time you use the medication. Your doctor may recommend treating fever and pain with an aspirin free pain reliever such as acetaminophen (Tylenol). Follow the label directions or your doctor's instructions about how much of this medicine to use.

What is nitroglycerin rectal?

Nitroglycerin is a nitrate that dilates (widens) blood vessels.

Nitroglycerin rectal is used to treat moderate to severe pain caused by chronic anal fissures (tears in the skin lining your rectum).

Nitroglycerin rectal may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using nitroglycerin rectal?

Multum emt

Do not use nitroglycerin rectal if you are taking sildenafil (Viagra, Revatio), avanafil (Stendra), tadalafil (Cialis), or vardenafil (Levitra). Serious, life-threatening side effects can occur if you use nitroglycerin rectal while you are using sildenafil.

Multum donot

You should not use this medication if you are allergic to:

  • isosorbide dinitrate (Dilatrate, Isordil, Isochron);
  • isosorbide mononitrate (Imdur, ISMO, Monoket); or
  • nitroglycerin used in a pill form or spray under the tongue, or as a skin patch or ointment (Minitran, Nitrek, Nitro-Bid, Nitro-Dur, Nitrolingual, Nitromist, Nitrostat, Nitro-Time, and others).
Multum donot

You also should not use nitroglycerin rectal if you have:

  • severe anemia (a lack of red blood cells); or
  • a brain injury, hemorrhage, or tumor.

Do not use this medication if you have early signs of a heart attack (chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling). Seek emergency medical attention if you have symptoms of a heart attack.

To make sure you can safely use nitroglycerin rectal, tell your doctor if you have any of these other conditions:

  • congestive heart failure;
  • a history of heart attack, stroke, or circulation problems;
  • low blood pressure;
  • glaucoma;
  • migraine headaches; or
  • liver disease.
Multum nopreg

FDA pregnancy category C. It is not known whether nitroglycerin will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

It is not known whether nitroglycerin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Multum nochild

Do not give this medication to anyone under 18 years old without medical advice.

How should I use nitroglycerin rectal?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

It may take up to 3 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse while using nitroglycerin ointment. Do not use this medication for longer than 3 weeks unless your doctor tells you to.

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Store at room temperature away from moisture and heat. Keep the tube tightly closed when not in use. Throw away any nitroglycerin rectal ointment you have not used within 8 weeks after you first opened the tube.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fainting.

What should I avoid while using nitroglycerin rectal?

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This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Multum noalcohol

Avoid drinking alcohol. It can increase some of the side effects of nitroglycerin, such as dizziness, drowsiness, feeling light-headed, or fainting.

What are the possible side effects of nitroglycerin rectal?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Nitroglycerin rectal can cause severe headaches, which may occur each time you use the medication. Your doctor may recommend treating fever and pain with an aspirin free pain reliever such as acetaminophen (Tylenol). Follow the label directions or your doctor's instructions about how much of this medicine to use.

Less serious side effects may include:

  • dizziness; or
  • mild headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect nitroglycerin rectal?

Many drugs can interact with nitroglycerin. Below is just a partial list. Tell your doctor if you are using:

  • alteplase (Activase);
  • aspirin or heparin;
  • dihydroergotamine (D.H.E. 45, Migranal) or ergotamine (Ergomar, Cafergot, and others);
  • heart or blood pressure medication such as atenolol (Tenormin, Tenoretic), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Dutoprol, Lopressor, Toprol), nadolol (Corgard), nebivolol (Bystolic), propranolol (Inderal, InnoPran), sotalol (Betapace), and others; or
  • nitroglycerin used in a pill form or spray under the tongue, or as a skin patch or skin ointment.

This list is not complete and there are many other drugs that can interact with nitroglycerin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about nitroglycerin.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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