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nafarelin nasal

Pronunciation: NAF a REL in

Brand: Synarel

What is the most important information I should know about nafarelin nasal?

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Nafarelin nasal can harm an unborn baby or cause birth defects. Do not use if you are pregnant.

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Do not breast-feed while using this medication.

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You should not use this medication if you are allergic to nafarelin or similar medicines such as leuprolide (Lupron, Eligard, Viadur), goserelin (Zoladex), histrelin (Vantas), or triptorelin (Trelstar).

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If you are a woman, you should not use nafarelin nasal if you have abnormal vaginal bleeding that has not been checked by a doctor; or if you are pregnant or breast-feeding.

Before using nafarelin nasal, tell your doctor if you have polycystic ovary disease, low bone mineral density, a history of osteoporosis, sneezing or a stuffy nose, diabetes, heart disease, high blood pressure, recent weight gain, high cholesterol, if you take steroids or seizure medication, if you smoke, or if you drink large amounts of alcohol.

Your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.

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Call your doctor at once if you have heavy or continued menstrual bleeding, pelvic pain or swelling, increased thirst, increased urination, chest pain or heavy feeling, pain spreading to the arm or shoulder, sweating or general ill feeling, sudden numbness or weakness, sudden severe headache, confusion, or problems with vision, speech, or balance.

What is nafarelin nasal?

Nafarelin nasal is a man-made form of a protein that is like a hormone in the body that helps regulate the menstrual cycle, fertility, and sexual development during puberty.

Nafarelin nasal is used to treat precocious puberty in both male and female children. It is also used to treat endometriosis in women who are 18 years of age or older.

Nafarelin nasal may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before using nafarelin nasal?

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You should not use this medication if you are allergic to nafarelin or similar medicines such as leuprolide (Lupron, Eligard, Viadur), goserelin (Zoladex), histrelin (Vantas), or triptorelin (Trelstar).

Multum donot

If you are a woman, you should not use nafarelin nasal if you have:

  • abnormal vaginal bleeding that has not been checked by a doctor; or
  • if you are pregnant or breast-feeding.

To make sure you can safely use nafarelin nasal, tell your doctor if you have any of these other conditions:

  • diabetes, heart disease, high blood pressure, recent weight gain, high cholesterol (especially in men);
  • polycystic ovary disease;
  • low bone mineral density;
  • a personal or family history of osteoporosis;
  • sneezing or a runny nose;
  • if you take steroids or seizure medication; or
  • if you smoke or drink large amounts of alcohol.
Multum nopreg

FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use nafarelin nasal if you are pregnant. Tell your doctor right away if you become pregnant during treatment.

Use a barrier form of birth control (such as a condom or diaphragm with spermicide). Hormonal contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment.

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It is not known whether nafarelin nasal passes into breast milk or if it could harm a nursing baby. Do not breast-feed while using this medication.

How should I use nafarelin nasal?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

To use the nasal spray:

  • Before the first use, prime the spray bottle by pumping it 5 to 10 times until a fine spray appears.
  • Gently blow your nose to clear any mucus. Uncap the spray bottle.
  • Insert the tip of the spray bottle into your nostril, pointing it straight upward. Block your other nostril with your finger. Quickly and gently pump the spray bottle one time and sniff gently at the same time. Remove the pump from your nose and tilt your head back slightly for a few seconds.
  • If using more than one spray per nostril, wait at least 30 seconds between each spray.
  • Clean the spray bottle tip with a tissue and recap it.

To be sure this medication is helping your condition and is not causing harmful effects, your doctor will need to check your progress on a regular basis, especially during the first 6 to 8 weeks of treatment. Do not miss any scheduled appointments.

When you first start using nafarelin nasal to treat precocious puberty, you may notice an increase in signs of puberty, such as enlarged breasts or vaginal bleeding. These are normal side effects of this medication during the first month of use. If such pubertal signs continue for longer than 1 month, contact your doctor.

Use nafarelin nasal regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

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Store in an upright position at room temperature, away from moisture, heat, and light. Keep the bottle upright when not in use.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

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Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking nafarelin nasal?

Try not to sneeze or blow your nose just after using the spray. This may decrease the amount of medication your body absorbs.

What are the possible side effects of nafarelin nasal?

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

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Call your doctor at once if you have a serious side effect such as:

  • heavy or continued menstrual bleeding;
  • pelvic pain or swelling;
  • increased thirst, increased urination;
  • seizure (convulsions);
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
  • sudden numbness or weakness, sudden severe headache, confusion, problems with vision, speech, or balance; or
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • changes in breast size;
  • oily skin or acne, increased body odor;
  • dandruff;
  • increase in pubic hair growth;
  • mood changes;
  • runny nose;
  • hot flashes;
  • mild headache, muscle pain;
  • light and occasional menstrual bleeding;
  • white or brownish vaginal discharge;
  • vaginal dryness; or
  • changes in sexual desire.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect nafarelin nasal?

If you have a stuffy nose during your treatment with nafarelin nasal, ask your doctor before using a decongestant. If your doctor recommends a decongestant nasal spray, do not use the decongestant for at least 2 hours after you have used nafarelin nasal.

There may be other drugs that can interact with nafarelin nasal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your pharmacist can provide more information about nafarelin nasal.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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