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naltrexone (injection)

Pronunciation: nal TREX own

Brand: Vivitrol

What is the most important information I should know about naltrexone injection?

Multum donot

Do not use narcotic drugs or alcohol while you are being treated with naltrexone injection. Never try to overcome the effects of the medication by using large doses of narcotic drugs or alcohol. Doing so could result in dangerous effects, including coma and death. Ask your doctor before using any prescription or over-the-counter medicine to treat a cold, cough, diarrhea, or pain during your treatment with naltrexone injection. These medicines may contain narcotics or alcohol.

Multum dizzy

Naltrexone injection may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

You may notice pain, redness, bruising, swelling, or a hard lump where the medication was injected. Call your doctor if you have this type of reaction to the shot, especially if it does not clear up or gets worse within 2 weeks.

Multum emt

Wear a medical alert tag or carry an ID card stating that you use naltrexone injection. Any medical care provider who treats you should know that you are receiving this medication.

Additional forms of counseling and/or monitoring may be recommended during treatment with naltrexone injection.

What is naltrexone injection?

Naltrexone blocks the effects of narcotic medicines and alcohol.

Naltrexone injection is used to treat addiction to alcohol or narcotic drugs. It is also used to prevent narcotic addiction relapse.

Naltrexone injection may also be used for purposes not listed in this medication guide.

What should I discuss with my health care provider before receiving naltrexone injection?

Multum donot

Do not receive this injection if you are allergic to naltrexone, or if you have:

  • an addiction to narcotics;
  • a history of alcohol or narcotic drug use within the past 7-10 days; or
  • drug or alcohol withdrawal symptoms.

To make sure you can safely use naltrexone injection, tell your doctor if you have any of these other conditions:

  • kidney disease;
  • liver disease; or
  • a bleeding disorder such as hemophilia.
Multum nopreg

FDA pregnancy category C. It is not known whether naltrexone injection will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Multum nobrfeed

It is not known whether naltrexone injection passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is naltrexone injection used?

Naltrexone injection is injected into a muscle. This injection is usually given once a month (every 4 weeks) and can be given only by a doctor or nurse in a clinic.

It is important to receive your naltrexone injections regularly to get the most benefit.

You may notice pain, redness, bruising, swelling, or a hard lump where the medication was injected. Call your doctor if you have this type of reaction to the shot, especially if it does not clear up or gets worse within 2 weeks.

Multum emt

Wear a medical alert tag or carry an ID card stating that you use naltrexone injection. Any medical care provider who treats you should know that you are receiving this medication.

Additional forms of counseling and/or monitoring may be recommended during treatment with naltrexone injection.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment to receive your naltrexone injection.

What happens if I overdose?

Multum emt

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, stomach pain, dizziness, or seizure (convulsions).

What should I avoid while using naltrexone injection?

Multum dizzy

Naltrexone injection may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Multum donot

Do not use narcotic drugs or alcohol while receiving naltrexone injection. Never try to overcome the effects of the medication by using large doses of narcotic drugs or alcohol. Doing so could result in dangerous effects, including coma and death. Ask your doctor before using any prescription or over-the-counter medicine to treat a cold, cough, diarrhea, or pain while you are being treated with naltrexone injection. These medicines may contain narcotics or alcohol.

What are the possible side effects of naltrexone injection?

Multum emt

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Multum donot

Call your doctor at once if you have any of these serious side effects:

  • blurred vision or eye problems;
  • fast heartbeat;
  • wheezing, difficulty breathing;
  • mood changes, hallucinations (seeing or hearing things), confusion, thoughts of hurting yourself;
  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • ear pain, ringing in your ears;
  • feeling light-headed, fainting;
  • skin rash or itching; or
  • pain, redness, bruising, itching, swelling, oozing, skin changes, or a hard lump where the medication was injected.

Less serious side effects may include:

  • feeling anxious, nervous, restless, or irritable;
  • increased thirst;
  • muscle or joint aches;
  • weakness or tiredness;
  • sleep problems (insomnia); or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect naltrexone injection?

The pain-relieving effects of any narcotic pain medications you use will be blocked if you use them during your treatment with naltrexone injection. Harmful side effects could also occur.

Tell your doctor about all other medicines you use, especially:

  • buprenorphine (Buprenex, Subutex);
  • butorphanol (Stadol);
  • codeine (Tylenol with codeine);
  • hydrocodone (Lortab, Vicodin);
  • hydromorphone (Dilaudid);
  • levorphanol (Levo-Dromoran);
  • meperidine (Demerol);
  • methadone (Dolophine, Methadose);
  • morphine (Kadian, MS Contin, Roxanol);
  • nalbuphine (Nubain);
  • naloxone (Narcan);
  • oxycodone (OxyContin, Roxicodone, Percocet);
  • oxymorphone (Numorphan); or
  • propoxyphene (Darvon, Darvocet).

This list is not complete and other drugs may interact with naltrexone injection. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor can provide more information about naltrexone injection.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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