Methotrexate for Psoriasis
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Methotrexate is a medicine that is usually taken once or twice a week.
It may also be given as a shot once a week.
How It Works
Methotrexate slows the rapid growth of skin cells in psoriasis.
Why It Is Used
Methotrexate is used to treat severe psoriasis (more than 20% of the skin is affected) when creams, ointments, tar products, and phototherapy have not worked or cannot be used. It is also used to treat psoriatic arthritis.
Methotrexate cannot be used by women who are pregnant or trying to become pregnant or by people:
How Well It Works
Methotrexate takes several weeks to show benefits. If side effects can be tolerated, methotrexate can work very well for some people. If you are taking methotrexate, your blood tests should be monitored carefully. And it is very important that you do not drink alcohol.
Common temporary side effects include:
- Nausea, fatigue, loss of appetite.
- Trouble sleeping.
- Low blood counts.
Less common temporary side effects include:
- Sunburn if you are exposed to large doses of sunlight or ultraviolet (UV) light either before or after taking the drug.
- Vomiting, diarrhea, and occasional blood in the stools.
- Mouth sores.
- Easy bruising and bleeding.
- Skin rash or sores.
- Chills and fever.
- Birth defects (if taken by a woman who is pregnant or who becomes pregnant while taking the medicine).
Long-term side effects include liver damage. If it is not severe, the damage reverses after you stop taking methotrexate. The risk of liver damage is higher if you drink a lot of alcohol, have kidney or liver problems or diabetes, or are overweight.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Because it can cause serious side effects, methotrexate is used only to treat severe psoriasis that cannot be treated with other medicines, such as psoriasis linked with arthritis (psoriatic arthritis).
People taking methotrexate need to have their blood counts and liver function tested before they start taking the drug and then regularly while they are taking it.
You may need to have a liver biopsy to check on the health of your liver while you are taking methotrexate.
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