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Uterine Leiomyosarcoma

National Organization for Rare Disorders, Inc.


It is possible that the main title of the report Uterine Leiomyosarcoma is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


  • leiomyosarcoma of the uterus

Disorder Subdivisions

  • None

General Discussion

A uterine leiomyosarcoma is a rare malignant (cancerous) tumor that arises from the smooth muscle lining the walls of the uterus (myometrium). There are essentially two types of muscles in the body: voluntary and involuntary. Smooth muscles are involuntary muscles; the brain has no conscious control over them. Smooth muscles react involuntarily in response to various stimuli. For example, the myometrium stretches during pregnancy to help accommodate the fetus and contracts during labor to help push out a baby during childbirth.

Leiomyosarcoma is a form of cancer. The term "cancer" refers to a group of diseases characterized by abnormal, uncontrolled cellular growth that invades surrounding tissues and may spread (metastasize) to distant bodily tissues or organs via the bloodstream, the lymphatic system, or other means. Different forms of cancer, including leiomyosarcomas, may be classified based upon the cell type involved, the specific nature of the malignancy, and the disease's clinical course.

Leiomyosarcoma is classified as a soft tissue sarcoma. Sarcomas are malignant tumors that arise from the connective tissue, which connects, supports and surrounds various structures and organs in the body. Soft tissue includes fat, muscle, never, tendons, tissue surrounding the joints (synovial tissue), and blood and lymph vessels. The exact cause of leiomyosarcoma, including uterine leiomyosarcoma, is unknown.


National Women's Health Network

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American Cancer Society, Inc.

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Tel: (404)320-3333

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OncoLink: The University of Pennsylvania Cancer Center Resource

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Philadelphia, PA 19104-4283


Tel: (215)349-8895

Fax: (215)349-5445



Sarcoma Foundation of America

9899 Main Street Ste 204

Damascus, MD 20872


Tel: (301)253-8687

Fax: (301)253-8690



Sarcoma Alliance

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Mill Valley, CA 94941


Tel: (415)381-7236

Fax: (415)381-7235



Rare Cancer Alliance

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Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

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Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223


Cancer Support Community

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Tel: (202)659-9709

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Lance Armstrong Foundation

2201 E. Sixth Street

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Tel: (512)236-8820

Fax: (512)236-8482

Tel: (877)236-8820




76 Ellsworth Street

San Francisco, CA 94110

Tel: (415)826-0474



Northwest Sarcoma Foundation

P.O. Box 91460

Portland, OR 97291

Tel: (503)954-5740



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site or email

Last Updated:  3/12/2012

Copyright  2007, 2012 National Organization for Rare Disorders, Inc.

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