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Multiple Sclerosis

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Multiple Sclerosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • MS
  • demyelinating disease
  • disseminated sclerosis
  • primary progressive multiple sclerosis
  • relapsing-remitting multiple sclerosis

Disorder Subdivisions

  • None

General Discussion

Multiple sclerosis is a chronic neuroimmunologic (both the nervous system and the immunological system are involved) disorder of the central nervous system involving the brain, spinal cord and optic nerves. By means of a mechanism not clearly understood, the protective fatty, insulating substance called myelin sheath that covers the nerve is destroyed. The inflammatory attacks that produce the characteristic scarring (plaques or patches) of the myelin sheath occurs randomly, vary in intensity, and at multiple sites. The course of the disease may advance, relapse, remit, or stabilize. The randomness of the location of plaques or patches affects the nerve's ability to transmit information (neurotransmission) and causes a wide range of neurological symptoms, which may vary from person to person.



Recently it has been learned that the nerve fibers themselves, (axons), in addition to the myelin sheaths, are affected by the neuroimmunologic attacks. Damage to the nerve cells may be irreversible. As a result, clinicians recommend early intervention with one of the disease-modifying agents (see below).

Resources

WE MOVE (Worldwide Education and Awareness for Movement Disorders)

5731 Mosholu Avenue

Bronx, NY 10471

USA

Tel: (347)843-6132

Fax: (718)601-5112

Email: wemove@wemove.org

Internet: http://www.wemove.org



National Multiple Sclerosis Society

1100 New York Avenue NW

Suite 660

Washington, DC 20005-3934

USA

Tel: (202)408-1500

Fax: (202)408-0696

Tel: (800)344-4867

Email: David.Chatel@nmss.org

Internet: http://www.nationalmssociety.org



American Autoimmune Related Diseases Association, Inc.

22100 Gratiot Ave.

Eastpointe, MI 48021

Tel: (586)776-3900

Fax: (586)776-3903

Tel: (800)598-4668

Email: aarda@aarda.org

Internet: http://www.aarda.org/



NIH/National Institute of Neurological Disorders and Stroke

P.O. Box 5801

Bethesda, MD 20824

Tel: (301)496-5751

Fax: (301)402-2186

Tel: (800)352-9424

TDD: (301)468-5981

Internet: http://www.ninds.nih.gov/



Consortium of Multiple Sclerosis Centers

359 Main Street

Suite A

Hackensack, NJ 07601

Tel: (201)487-1050

Fax: (201)678-2290

Email: info@mscare.org

Internet: http://www.mscare.org



Multiple Sclerosis Association of America

706 Haddonfield Road

Cherry Hill, NJ 08002

USA

Tel: (856)488-4500

Fax: (856)661-9797

Tel: (800)532-7667

Email: ctalbot@msassociation.org

Internet: http://www.msassociation.org/



Multiple Sclerosis International Federation

3rd Floor Skyline House

200 Union Street

London, SE1 0LX

United Kingdom

Tel: 4402076201911

Fax: 4402076201922

Email: info@msif.org

Internet: http://www.msif.org/en/



Spastic Paraplegia Foundation

5305 Miramar Ln

Colleyville, TX 76034

USA

Tel: (877)773-4483

Email: information@sp-foundation.org

Internet: http://sp-foundation.org



Christopher & Dana Reeve Foundation

636 Morris Turnpike, Suite 3A

Short Hills, NJ 07078

USA

Tel: (973)379-2690

Fax: (973)912-9433

Tel: (800)225-0292

Email: prc@ChristopherReeve.org

Internet: http://www.christopherreeve.org



New Horizons Un-Limited, Inc.

811 East Wisconsin Ave

P.O. Box 510034

Milwaukee, WI 53203

USA

Tel: (414)299-0124

Fax: (414)347-1977

Email: horizons@new-horizons.org

Internet: http://www.new-horizons.org



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



Madisons Foundation

PO Box 241956

Los Angeles, CA 90024

Tel: (310)264-0826

Fax: (310)264-4766

Email: getinfo@madisonsfoundation.org

Internet: http://www.madisonsfoundation.org



Autoimmune Information Network, Inc.

PO Box 4121

Brick, NJ 08723

Fax: (732)543-7285

Email: autoimmunehelp@aol.com



European Society for Immunodeficiencies

1-3 rue de Chantepoulet

Geneva, CH 1211

Switzerland

Tel: 410229080484

Fax: 41229069140

Email: esid@kenes.com

Internet: http://www.esid.org



Multiple Sclerosis Foundation

6520 North Andrews Avenue

Ft. Lauderdale, FL 33309-2130

Tel: (954)776-6805

Fax: (954)938-8708

Tel: (800)225-6495

Email: admin@msfocus.org

Internet: http://www.msfocus.org



AutoImmunity Community

Email: moderator@autoimmunitycommunity.org

Internet: http://www.autoimmunitycommunity.org



PLAN Institute for Caring Citizenship

Suite 260 - 3665 Kingsway

Vancouver

British Columbia, V5R 5W2

Canada

Tel: 6044399566

Fax: 6044397001

Email: inquiries@planinstitute.ca

Internet: http://www.planinstitute.ca/?q=learnfromus/library



Child Neurology Foundation

2000 West 98th Street

Bloomington, MN 55431

USA

Tel: (952)641-6100

Fax: (952)881-6276

Tel: (877)263-5430

Email: jstone@childneurologyfoundation.org

Internet: http://www.childneurologyfoundation.org



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to MyD-H, the Dartmouth-Hitchcock patient portal. You must be a registered MyD-H user for the Lebanon, Manchester, or Nashua locations to access this site.

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  3/29/2012

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