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Sarcoidosis

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Sarcoidosis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Schaumann's Disease
  • Sarcoid of Boeck

Disorder Subdivisions

  • Acute Sarcoidosis; Heerferdt-Waldenstrom and Lofgren's Syndromes (Included)
  • Subacute Sarcoidosis
  • Chronic Sarcoidosis

General Discussion

Sarcoidosis is a multisystem disorder that most often affects individuals between 20 and 40 years of age. Females appear to be affected more frequently than males. Sarcoidosis is characterized by the abnormal formation of inflammatory masses or nodules (granulomas) consisting of certain granular white blood cells (modified macrophages or epithelioid cells) in certain organs of the body. The granulomas that are formed are thought to alter the normal structure of and, potentially, the normal functions of, the affected organ(s), causing symptoms associated with the particular body system(s) in question. In individuals with sarcoidosis, such granuloma formation most commonly affects the lungs. However, in many cases, the upper respiratory system, lymph nodes, skin, and/or eyes may be involved. In addition, in some cases, other organs may be affected, including the liver, bone marrow, spleen, musculoskeletal system, heart, salivary glands, and/or nervous system (i.e., central or peripheral nervous system).



The range and severity of symptoms associated with sarcoidosis vary greatly, depending upon the specific organ(s) involved and the degree of such involvement. In some cases, the symptoms of sarcoidosis may begin suddenly (acute), sometimes severely, and subside in a relatively short period of time (self limited). Acute sarcoidosis is often characterized by fatigue, fever, generalized muscle aches, difficulty breathing (dyspnea), joint pain, swollen glands, skin eruptions, eye irregularities, and/or other symptoms. In the subacute form, affected individuals may experience no symptoms (asymptomatic), even with organ involvement. In the chronic form of sarcoidosis, symptoms may appear slowly and subtly, and may persist or recur over a long time span. Initial symptoms of the chronic form of the disorder may include difficulty breathing (dyspnea), dry cough, limited airflow, and other respiratory abnormalities. Symptoms associated with other organ involvement may follow.



The exact cause of sarcoidosis is not known. However, possible infectious, environmental, genetic, and immunological factors are under investigation as potential causes of the disorder.

Resources

American Autoimmune Related Diseases Association, Inc.

22100 Gratiot Ave.

Eastpointe, MI 48021

Tel: (586)776-3900

Fax: (586)776-3903

Tel: (800)598-4668

Email: aarda@aarda.org

Internet: http://www.aarda.org/



American Lung Association

1301 Pennsylvania Ave NW

Suite 800

Washington, DC 20004

USA

Tel: (202)785-3355

Fax: (202)452-1805

Tel: (800)586-4872

Email: info@lungusa.org

Internet: http://www.lungusa.org



NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases

Information Clearinghouse

One AMS Circle

Bethesda, MD 20892-3675

USA

Tel: (301)495-4484

Fax: (301)718-6366

Tel: (877)226-4267

TDD: (301)565-2966

Email: NIAMSinfo@mail.nih.gov

Internet: http://www.niams.nih.gov/



NIH/National Eye Institute

31 Center Dr

MSC 2510

Bethesda, MD 20892-2510

United States

Tel: (301)496-5248

Fax: (301)402-1065

Email: 2020@nei.nih.gov

Internet: http://www.nei.nih.gov/



NIH/National Heart, Lung and Blood Institute

P.O. Box 30105

Bethesda, MD 20892-0105

Tel: (301)592-8573

Fax: (301)251-1223

Email: nhlbiinfo@rover.nhlbi.nih.gov

Internet: http://www.nhlbi.nih.gov/



National Sarcoidosis Resource Center

P.O. Box 1593

Piscataway, NJ 08855-1593

Tel: (732)699-0733

Fax: (732)699-0882

Email: sconroy846@aol.com

Internet: http://www.nsrc-global.net



Sarcoid Networking Association

5302 South Sheridan Avenue

Tacoma, WA 98408-3535

Tel: (253)826-7737

Fax: (253)826-7737

Email: sarcoidinformation@sarcoidosisnetwork.org

Internet: http://www.sarcoidosisnetwork.org



Sarcoidosis Online Sites (S.O.S.)

P.O. Box 150549

Cape Coral, FL 33915

Tel: (239)945-2414

Email: SarcoidosisOnlineSites@gmail.com

Internet: http://www.sarcoidosisonlinesites.com



Sarcoidosis Center

6005 Park Ave

Suite 501

Memphis, TN 38119

USA

Tel: (901)761-5877

Fax: (901)761-2280

Email: sarcoid@sarcoidcenter.com

Internet: http://www.sarcoidcenter.com



Ocular Immunology and Uveitis Foundation

5 Cambridge Center

8th Floor

Cambridge, MA 02142

Tel: (617)621-6377

Fax: (781)431-2042

Tel: (866)353-6377

Email: fosters@comcast.net

Internet: http://www.uveitis.org



Foundation for Sarcoidosis Research

1820 West Webster Avenue

Suite #304

Chicago, IL 60614

USA

Tel: (312)341-0500

Fax: (312)322-9808

Tel: (866)358-5477

Email: info@stopsarcoidosis.org

Internet: http://www.stopsarcoidosis.org



Erythema Nodosum Yahoo Support Group

Internet: http://health.groups.yahoo.com/group/erythema_nodosum_Group/



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



Center for Peripheral Neuropathy

University of Chicago

5841 South Maryland Ave, MC 2030

Chicago, IL 60637

Tel: (773)702-5659

Fax: (773)702-5577

Internet: http://peripheralneuropathycenter.uchicago.edu/



Madisons Foundation

PO Box 241956

Los Angeles, CA 90024

Tel: (310)264-0826

Fax: (310)264-4766

Email: getinfo@madisonsfoundation.org

Internet: http://www.madisonsfoundation.org



Autoimmune Information Network, Inc.

PO Box 4121

Brick, NJ 08723

Fax: (732)543-7285

Email: autoimmunehelp@aol.com



European Society for Immunodeficiencies

1-3 rue de Chantepoulet

Geneva, CH 1211

Switzerland

Tel: 410229080484

Fax: 41229069140

Email: esid@kenes.com

Internet: http://www.esid.org



Janine Sarcoidosis Outreach Foundation

12600 Bissonnet

A4

Houston, TX 77099

Tel: (832)248-6621

Fax: (281)568-5775

Tel: (800)846-5158

Email: sarcoidosis@jsof.org

Internet: http://www.jsof.org/



AutoImmunity Community

Email: moderator@autoimmunitycommunity.org

Internet: http://www.autoimmunitycommunity.org



National Sarcoidosis Organization

RR#1

Sundre

Alberta, T0M 1X0

Canada

Tel: 4035569833

Email: info@nationalsarcoidosisorganization.com

Internet: http://www.nationalsarcoidosisorganization.com



Sarcoidosis & Lyme Disease Support Australia

PO Box 629

Narellan, NSW 2567

Australia

Tel: 488603532

Email: support@sarcoidosisaustralia.com

Internet: http://www.sarcoidosisaustralia.com



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to MyD-H, the Dartmouth-Hitchcock patient portal. You must be a registered MyD-H user for the Lebanon, Manchester, or Nashua locations to access this site.

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  5/2/2008

Copyright  1986, 1992, 1993, 1996, 1997, 1998, 1999, 2002, 2004 National Organization for Rare Disorders, Inc.

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