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Amyloidosis

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Amyloidosis is not the name you expected.

Disorder Subdivisions

  • familial amyloidosis
  • primary amyloidosis
  • secondary amyloidosis
  • senile amyloidosis

General Discussion

Amyloidosis is a systemic disorder that is classified into several types. The different types of systemic amyloidosis are classified as primary, secondary or familial (hereditary). Primary amyloidosis (also called AL, or ‘light chain') is the most common type of systemic amyloidosis. AL results from an abnormality (dyscrasia) of plasma cells (a type of white blood cell) in the bone marrow and is closely related to multiple myeloma. Secondary (AA) amyloidosis is derived from the inflammatory protein serum amyloid A. AA occurs in association with chronic inflammatory disease such as the rheumatic diseases, familial Mediterranean fever, chronic inflammatory bowel disease, tuberculosis or empyema. Familial amyloidosis is a rare type of amyloidosis that is caused by an abnormal gene. There are several abnormal genes that can cause hereditary amyloidosis, but the most common type of hereditary amyloidosis is called ATTR and caused by mutations in the transthyretin (TTR) gene.



Senile amyloidosis, in which the amyloid is derived from wild-type (normal) transthyretin, is a slowly progressive disease that affects the hearts of elderly men. Amyloid deposits may occasionally occur in isolation without evidence of a systemic disease; isolated bladder or tracheal amyloid are the most common such presentations.

Resources

International Myeloma Foundation

12650 Riverside Drive

Suite 206

North Hollywood, CA 91607

USA

Tel: (818)487-7455

Fax: (818)487-7454

Tel: (800)452-2873

Email: TheIMF@myeloma.org

Internet: http://www.myeloma.org



Multiple Myeloma Research Foundation

383 Main Avenue

5th Floor

Norwalk, CT 06851

USA

Tel: (203)229-0464

Fax: (203)229-0572

Email: info@themmrf.org

Internet: http://www.themmrf.org/



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



Amyloidosis Support Groups

232 Orchard Drive

Wood Dale, IL 60191

Tel: (847)350-7540

Fax: (847)350-0577

Tel: (866)404-7539

Email: muriel@finkelsupply.com

Internet: http://www.amyloidosissupport.com



Amyloidosis Foundation

7151 N. Main Street

Suite 2

Clarkston, MI 48346

Tel: (248)922-9610

Fax: (248)922-9620

Tel: (877)269-5643

Email: modonnell@amyloidosisresearchfoundation.org

Internet: http://www.amyloidosis.org



Who is Amy?

3856 Winona Ct.

Denver, CO 80212

Tel: (303)917-9888

Fax: (720)536-4661

Email: becca.barry@whoisamy.org

Internet: http://www.whoisamy.org



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to MyD-H, the Dartmouth-Hitchcock patient portal. You must be a registered MyD-H user for the Lebanon, Manchester, or Nashua locations to access this site.

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  3/12/2013

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