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Wolf Hirschhorn Syndrome

National Organization for Rare Disorders, Inc.


It is possible that the main title of the report Wolf Hirschhorn Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.


  • WHS
  • Wolf Syndrome
  • Wolf-Hirschhorn Chromosome Region (WHCR)
  • WHCR
  • Chromosome 4, Partial Deletion 4p
  • Partial Deletion of the Short Arm of Chromosome 4
  • Chromosome 4, Partial Monosomy 4p
  • 4p- Syndrome, Partial
  • Pitt-Rogers-Danks Syndrome

Disorder Subdivisions

  • None

General Discussion

Wolf-Hirschhorn syndrome is an extremely rare chromosomal disorder caused by a partial deletion (monosomy) of the short arm ("p") of chromosome 4. Major symptoms may include extremely wide-set eyes (ocular hypertelorism) with a broad or beaked nose, a small head (microcephaly), low-set malformed ears, mental and growth deficiency, heart (cardiac) defects, and seizures. Because the amount of genetic material deleted varies, the symptoms of this syndrome vary from case to case.


Chromosome Disorder Outreach, Inc.

P.O. Box 724

Boca Raton, FL 33429-0724


Tel: (561)395-4252

Fax: (561)395-4252



4P- Support Group

3200 Rivanna Court

Woodbridge, VA 22192

United States

Tel: (715)248-3937



Wolf Hirschhorn Syndrome Trust for the UK and Ireland

1 Hawthorne Villas

Holmes Chapel

Crewe, CW4 7AR

United Kingdom

Tel: 08456035338



World Health Organization (WHO)

Avenue Appia 20

Geneva 27, 1211


Tel: 41227912111

Fax: 41227913111


Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223


Madisons Foundation

PO Box 241956

Los Angeles, CA 90024

Tel: (310)264-0826

Fax: (310)264-4766



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site or email

Last Updated:  4/7/2008

Copyright  1989, 1992, 1995, 1996, 1998, 2005 National Organization for Rare Disorders, Inc.

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