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Motor Neuron Disease

National Organization for Rare Disorders, Inc.

Important

It is possible that the main title of the report Motor Neuron Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

  • Motoneuron Disease
  • Motoneurone Disease
  • Motor Neuron Syndrome
  • Motor Neurone Disease

Disorder Subdivisions

  • Progressive Bulbar Palsy
  • Amyotrophic Lateral Sclerosis
  • Spinal Muscular Atrophy, All Types
  • Kugelberg-Welander Syndrome
  • Lou Gehrig's Disease, Included
  • Duchenne's Paralysis
  • Werdnig-Hoffmann Disease
  • Juvenile Spinal Muscular Atrophy
  • ALS Included
  • Benign Focal Amyotrophy
  • Infantile Spinal Muscular Atrophy (all types)

General Discussion

Motor neuron disease comprises a group of severe disorders of the nervous system characterized by progressive degeneration of motor neurons (neurons are the basic nerve cells that combine to form nerves). Motor neurons control the behavior of muscles. Motor neuron diseases may affect the upper motor neurons, nerves that lead from the brain to the medulla (a part of the brain stem) or to the spinal cord, or the lower motor neurons, nerves that lead from the spinal cord to the muscles of the body, or both. Spasms and exaggerated reflexes indicate damage to the upper motor neurons. A progressive wasting (atrophy) and weakness of muscles that have lost their nerve supply indicate damage to the lower motor neurons.

Resources

Amyotrophic Lateral Sclerosis Association

27001 Agoura Road

Suite 250

Calabasas Hills, CA 91301-5104

USA

Tel: (818)880-9007

Fax: (818)880-9006

Tel: (800)782-4747

TDD: (818)593-3540

Email: als@alsa-national.org

Internet: http://www.alsa.org



Families of Spinal Muscular Atrophy

925 Busse Road

Elk Grove Village, IL 60007

Tel: (847)367-7620

Tel: (800)886-1762

Email: sma@fsma.org

Internet: http://www.fsma.org/



Motor Neurone Disease Association

PO Box 246

Northampton, NN1 2BG

United Kingdom

Tel: 01604250505

Fax: 441604624726

Email: enquiries@mndassociation.org

Internet: http://www.mndassociation.org



Muscular Dystrophy Association

3300 East Sunrise Drive

Tucson, AZ 85718-3208

USA

Tel: (520)529-2000

Fax: (520)529-5300

Tel: (800)572-1717

Email: mda@mdausa.org

Internet: http://www.mda.org/



NIH/National Institute of Neurological Disorders and Stroke

P.O. Box 5801

Bethesda, MD 20824

Tel: (301)496-5751

Fax: (301)402-2186

Tel: (800)352-9424

TDD: (301)468-5981

Internet: http://www.ninds.nih.gov/



MND Scotland

76 Firhill Rd

Glasgow, G20 7BA

Scotland

Tel: 01419451077

Fax: 01419452578

Email: info@mndscotland.org.uk

Internet: http://www.mndscotland.org.uk/



International Alliance of ALS/MND Associations

P.O. Box 246

Northampton, NN1 2PR

United Kingdom

Tel: 441604611821

Fax: 441604624726

Email: alliance@alsmndalliance.org

Internet: http://www.alsmndalliance.org



Genetic and Rare Diseases (GARD) Information Center

PO Box 8126

Gaithersburg, MD 20898-8126

Tel: (301)251-4925

Fax: (301)251-4911

Tel: (888)205-2311

TDD: (888)205-3223

Internet: http://rarediseases.info.nih.gov/GARD/



Association for Frontotemporal Degeneration

Radnor Station Building #2, Suite 320

290 King of Prussia Road

Radnor, PA 19087

Tel: (267)514-7221

Tel: (866)507-7222

Email: info@theaftd.org

Internet: http://www.theaftd.org



For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  9/23/2007

Copyright  1989, 1992, 1999, 2006, 2007 National Organization for Rare Disorders, Inc.

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