Research Programs

 

 

Cancer Epidemiology

The Cancer Epidemiology and Chemoprevention Research Program is a multidisciplinary interaction between laboratory investigators, biostatisticians, epidemiologists, and clinicians, who work to understand the etiology and mechanisms involved in the chemoprevention of cancer.

Focus on Epidemiology & Chemoprevention

Brussel Sprouts, Beer…and Arsenic?

Dartmouth researchers analyzed toenail clippings to measure long-term arsenic levels in the body. They found significantly increased exposure in people who regularly consume beer, white wine, Brussel sprouts, and dark meat fish.

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Program Co-Directors:
Margaret Karagas, PhD
Carmen J. Marsit, PhD

This Program fosters discovery of novel chemopreventive agents, identification of their major biologic targets, and the use of markers of early biologic response in pre-clinical and animal models of pre-neoplasia or neoplastic disease as well as in the conduct of hypothesis-driven clinical trials.

The Program promotes investigations that identify carcinogenic factors and their effects at the molecular, genetic, biochemical and population levels and fosters inquiry into the environmental and biological factors that modify these effects. Collectively, these efforts involve observation studies, clinical trials, animal models with carcinogen-induced tumors and genetically engineered animals (primarily rodent species), and in vitro studies.

The long-term goal of this Program is to identify and develop interactions that inhibit carcinogenesis. Once these interventions are found through use of pre-clinical and experimental animal models, then initial clinical exploration will be undertaken through proof-of-principle Phase I/II trials. Findings will be confirmed and extended ultimately through definitive Phase III trials that pursue mechanism-based chemopreventive interventions.

The Program aims to continue to strengthen its scientific accomplishments by organizing and encouraging intra-programmatic and inter-programmatic interactions as well as interactions with visiting scientists who are leaders in the chemoprevention field. These interactions are intended to foster collaborative and interdisciplinary projects among epidemiologists, basic scientists, and clinicians who share a commitment to advance the scientific goals of the Program.