Focus on Cancer Mechanisms
Cancer cells misbehave by dividing and traveling to places they aren't supposed to go. A cell's DNA (deoxyribonucleic acid) tells it what to do: a standard DNA sequence is well ordered and gives proper instructions. But when DNA is damaged, it can send out wrong information.
CM's emphasis is to elucidate pathways that present opportunities as well as challenges in cancer diagnosis, classification, prevention, and treatment. All CM members have research interests in basic cancer mechanisms, including the normal functions of oncogenes and tumor suppressor genes; regulators of cell cycle and apoptosis; regulators of angiogenesis and metastasis; and stem cells and blood formation.
The Program adds value by channeling intellectual effort, collaborations, access to shared resources, and developmental funds toward three translational aims: molecular disease classification; drug target and lead compound identification; and understanding the complex interactions of small molecules and genotypes in carcinogenesis and treatment.