Research Programs

 

 

Focus on Science & Research

Focus is the online newsletter for Norris Cotton Cancer Center.

News is posted as it happens, making Focus the most up-to-date source of information about the developments and people at the Cancer Center.

Below are all the Focus articles related specifically to cancer science and research. All Focus articles are also available.

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Putting a Parasite to Work

From the litter box to the laboratory, a microscopic organism native to cats shows promise in treating cancer. Dartmouth researchers’ mutated strain of T. gondii reprograms the natural power of the immune system to kill cells.

July 08, 2014

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Unraveling Ovarian Cancer

By comparing the genetic makeup of ovarian tumors from two very different groups of women, researchers hope to discover what irregularities in DNA are shared because that could point to the cause of this deadly disease.

May 13, 2014

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Room to Operate

MRI and CT scanners slide in and out of operating rooms on overhead rails giving surgeons real-time 3-D images of complex organs like brains and spines. Students observe from a balcony overhead. This changes everything.

April 14, 2014

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Large Hopes, Small Tools

Nanoparticles can slip though the lining of cancer cells and, once inside, release anti-cancer agents. Researchers are using these tiny tools to deliver heat inside cancer cells to kill them without damaging adjacent healthy cells.

March 24, 2014

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Is It or Isn’t It Breast Cancer?

By adding near-infrared spectroscopy to MRI, doctors can learn more about the abnormality’s oxygen level, blood flow, and lipids.

February 03, 2014

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A Scientific First

A scientific breakthrough may give the field of radiation oncology new tools to increase the precision and safety of radiation treatment in cancer patients by helping doctors “see” the powerful beams of a linear accelerator as they enter or exit the body.

January 20, 2014

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Brussel Sprouts, Beer…and Arsenic?

Dartmouth researchers analyzed toenail clippings to measure long-term arsenic levels in the body. They found significantly increased exposure in people who regularly consume beer, white wine, Brussel sprouts, and dark meat fish.

December 20, 2013

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Using a Parasite to Fight Cancer

Instead of removing tumors surgically, can we inject them with a "poison" that would cause them to destroy themselves? Scientists experiment in the lab with ways to use a common parasite in future treatment for cancer.

November 04, 2013

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Osteoporosis and Esophageal Cancer

Common treatments for osteoporosis (bisphosphonates like Boniva or Fosamax), prescribed to strengthen bones and reduce the risk of fracture, can irritate the esophagus in some patients. Do these drugs increase your risk for cancer?

October 18, 2013

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Using Media to Promote Healthy Behavior

Studies show that children are influenced—often in unhealthy ways—by ads using popular movie and TV characters. Dartmouth researchers want to use these marketing tactics to promote healthy behaviors.

September 23, 2013

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Who Is Most Likely to Have Thyroid Cancer?

Thyroid cancer is the third fastest rising cancer diagnosis in the United States. The number of thyroid cancer diagnoses has more than tripled in the last 30 years, but the number of people who have died from the disease remains the same. Is this "thyroid cancer epidemic" due to an increase in the disease or because insurance-covered screening detects small tumors that may never cause symptoms or harm?

August 19, 2013

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Turning Discoveries into Treatments: Randy Noelle PhD

Geisel School of Medicine’s Randy Noelle and researchers in his lab recently discovered a protein that might be used to help the body’s immune system attack cancer tumors. He’s co-founded a company, ImmuNext, to turn his discovery into a viable treatment.

July 01, 2013

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Alcohol Movie Rating Could Help with Underage Drinking

Movies showing underage drinking, binge drinking, alcohol abuse, or drinking and driving can influence adolescent behavior. Should they be R-rated?

June 24, 2013

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Gene Mutations Contribute to Lung Cancer Risk

For people with a certain genetic pattern, even light cigarette use increases lung cancer risk, increases nicotine dependence, and makes it harder to quit.

June 03, 2013

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Team Science helps Identify Genetic Influence in Obesity for People of African Ancestry

Genetic variations work with environmental factors to influence body size and obesity.

May 13, 2013

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New Tool Measures Secondhand Smoke

You know exposure to secondhand smoke is unhealthy. What if you had a tool to help explain the risks to well intentioned, back-porch-smoking relatives and friends?

April 22, 2013

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New Research Disrupts Cancer's Feeding Cycle

Keeping cancer cells from the fat they need to grow: researchers' work brings detours from the lab… to dairy barns and gyms.

March 11, 2013

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Protect Children from Third Hand Smoke Exposure

How tobacco smoke lives and lingers long after the smoke has "supposedly" cleared.

February 04, 2013

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Study Evaluates Newer Treatment for Women Whose Breast Cancer Has Spread

Results from a phase III clinical trial comparing a newer chemotherapy agent called eribulin mesylate with capecitabine, a standard drug used for chemotherapy today in women with previously treated metastatic breast cancer, showed that eribulin demonstrated a trend toward improved overall survival.

January 07, 2013

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What is the Future of Microwave Technology in Diagnostic Imaging?

Norris Cotton Cancer Center has used microwave imaging to study soft tissue. But researchers asked if it can do more than detect breast tumors? Results show it may be able to measure bone density.

December 10, 2012

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Popular Pain Relievers and Bladder Cancer

Duration of ibuprofen use may be related to a reduced cancer risk, especially in those with certain genetic marker.

November 05, 2012

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Which Fish Should I Eat?

After reviewing numerous fish advisories, researchers conclude that we need simpler consumer guidelines and more stringent fish management policies.

October 15, 2012

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Fast Food Access and Family Habits

When a town has no traffic lights, pizza delivery or drive-through windows... Does rural living lead to healthier eating?

September 24, 2012

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From Rivers to Research

One good way to learn how to lead team-building collaboration is to tell people where the big rocks in the river are.

September 17, 2012

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National Melanoma Symposium on Sept 22nd

For patients, their families, and people interested in exploring the critical health issues surrounding malignant melanoma.

September 04, 2012

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Rate Films with Smoking "R" and Cut Smoking Onset by Teens

New Cancer Center research uncovers, for the first time, the impact of an R rating for movie smoking. And it's a big impact.

July 16, 2012

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Making the Case for Funding Cancer Research

"Cancer researchers from all over the world come here to New Hampshire to be part of Norris Cotton Cancer Center because we are a leader in cancer prevention and control research," says Mark Israel, MD, Director of the Cancer Center.

June 28, 2012

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A Stitch in Time with Cancer Research

Upon approaching Lilian Kabeche's desk in the Duane Compton lab in the Remsen research building at the Geisel School of Medicine at Dartmouth, the first thing that a visitor notices is the bubblegum pink lab coat hanging from her chair.

May 29, 2012

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Sifting Through "Junk" for Colorectal Cancer Clues

Two Cancer Center researchers at the Geisel School of Medicine at Dartmouth have helped to identify switches that can turn on or off genes associated with colorectal cancer.

May 17, 2012

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Helping Women Help Themselves

One of the most satisfying aspects of Tracy Onega's work with the New Hampshire Mammography Network (NHMN), she says, is creating an opportunity for the women of New Hampshire to feel like they are contributing to a significant public-health outcome.

May 07, 2012

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Can a Cancer Drug Combo Be Too Effective?

Even so, a new drug combination offers "real potential" in leukemia therapy, says Alan Eastman, PhD.

March 26, 2012

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Surgeon General Cites Cancer Center Studies in New Youth Smoking Report

It's shocking. Every day, more than 1,200 people in the United States die from smoking-related causes—more than 440,000 Americans every year.

March 19, 2012

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A Glimmer of Hope Against Pancreatic Cancer

Cancer Center researchers test a new screening protocol that offers hope that deadly pancreatic cancer will soon be caught earlier rather than later.

February 06, 2012

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Fast Food in the Movies

Kids are getting an eyeful of positive fast-food impressions every time they go to the movies.

December 26, 2011

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40 Years After the National Cancer Act

Forty years ago, President Richard Nixon signed the National Cancer Act, creating a nationwide program to fight cancer. Cancer Center director Mark Israel, MD, spoke to VPR about the progress that has been made since.

December 20, 2011

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Cancer Center Researchers Cited for Major Advances in 2011 by ASCO

Research by members of Norris Cotton Cancer Center has been cited by the American Society of Clinical Oncology as noteworthy advancements in 2011 in the effort to improve cancer treatment and prevention.

December 16, 2011

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Two Cancer Center Researchers Named AAAS Fellows

Two members of Norris Cotton Cancer Center's research team have been selected as 2011 fellows by the American Association for the Advancement of Science (AAAS), the world's largest general scientific society and the publisher of the journal Science.

December 09, 2011

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Rice Evaluated as Source of Fetal Arsenic Exposure

New Dartmouth research underscores concerns about arsenic levels in rice and risks for pregnant women.

December 05, 2011

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Dartmouth Researchers Identify a New Pioneer Factor

Cancer Center researchers have discovered that the presence of a novel pioneer factor (PBX1) in breast cancer cells can direct the response to estrogen.

November 18, 2011

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The Next Generation to Look for a Cure

Dartmouth students learn the ins and outs of being a cancer researcher as part of a new organization seeking to attract bright young minds to the field.

November 07, 2011

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Dartmouth Receives $6.1M Women's Breast Cancer Grant

A new Breast Cancer Screening Center will develop and test new informational tools to help women understand the benefits of screening.

October 24, 2011

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New $11M Biomedical Collaborative Grant for the Cancer Center

A new Center of Biomedical Research Excellence at Dartmouth networks with several of New England's most important educational institutions.

October 18, 2011

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From Bench to Bedside and Back Again

After more than 10 years of work, a Cancer Center research team has found a very promising drug combination therapy for lung cancer patients.

October 11, 2011

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Finding Answers in Clinical Research

A conversation with Marc Ernstoff, MD, the Cancer Center's new Associate Director for Clinical Research.

September 19, 2011

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An Investment in Promise

Cell biologist Jamie Moseley was recently selected as the recipient of a very competitive research award administered by the Pew Charitable Trusts.

June 14, 2011

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Rural Mothers and Exercise

A new Cancer Center study found that rural mothers perceive specific internal barriers to being adequately physically active.

April 28, 2011

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Looking for Mastectomy Alternatives

Dartmouth cancer researchers Michael Sporn, MD, and Karen Liby, PhD, continue their research into promising new agents for preventing ER-negative breast cancer.

April 27, 2011

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A Numbers Game

"The question policymakers have to ask themselves is, 'Who would benefit the most screening?' It’s easy to say, 'Everyone,' but in an era of limited resources that’s not a useful answer." – Samir Soneji, PhD

April 26, 2011

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The First Steps toward an Anti-Tumor Vaccine

New research headed by Richard Barth, MD, points the way toward creating personalized vaccines that one day may help patients with colorectal cancer develop an immune response against their own tumors.

April 15, 2011

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The Cancer Collaborators

Dartmouth is known for its innovative interdisciplinary research, and Norris Cotton Cancer Center is often the bridge-builder of exciting, collaborative science.

April 10, 2011

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Research Links HPV Infection to Increased Risk for Skin Cancer

A research team led by the Cancer Center's Margaret Karagas, PhD, has found that people with several skin types of human papillomaviruses were more likely to develop certain skin cancers compared to people with no HPVs.

October 27, 2010

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New Study Helps Explain Protein Function in Tumor Cell Growth

New research from the Cancer Center helps explain why the Myc protein, found in the nucleus of cells and crucial to the function of cell division, sometimes reaches elevated levels that cause it to be an agent in the growth of cancerous tumors.

October 26, 2010

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The Building Blocks of a Cure

"We want to know everything about the types that resist chemotherapy so that we can raise the cure rate for all types of leukemia," says Patricia Ernst, PhD.

July 25, 2010

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By the Numbers

Medical consumers face an increasingly dense thicket of statistical claims about medicines, procedures, and tests.

July 10, 2010

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Fueling Research to Solve the Problems

If you happen to be in the DHMC parking lots in the wee hours, you'll see lights beaming out of the Norris Cotton Cancer Center and Borwell research labs.

April 27, 2010

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Disrupting the Pathways to Cancer

Our cells communicate with each other along pathways using the language of chemical signals.

April 15, 2010

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Fighting Cancers with "T" Cells

Imagine a cancer treatment made from particles so small, they fit through the pores in capillary walls and can be readily engulfed by cells.

April 10, 2010

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Part of the Possibility

On meeting Cindy Carroll one might be tempted to describe her as petite. She's slight of build and just over five feet tall. Talk to her for any length of time, however, and that impression quickly changes.

October 20, 2009

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Nanoparticle Therapy: Promising New Directions in Ovarian Cancer Treatment

Imagine a cancer treatment made from particles so small, they fit through the pores in capillary walls and can be readily engulfed by cells.

October 10, 2009

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Advances in Research

Barbara Conradt, PhD, studies apoptosis in Caenorhabditis elegans, a tiny roundworm that has taught scientists much of what they know about the way cell death works in humans.

January 25, 2009

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Looking for Cancer's Fingerprint

Doctors, like detectives, rely on clues. When cancer is suspected, it's important to have as much information as possible in order to make the correct diagnosis and prescribe the best treatment plan.

January 20, 2009

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Murray Korc: Putting Principles into Practice

As both a physician and a scientist, Murray Korc, MD, strives to bring new treatments from the lab bench to the hospital bed.

January 10, 2009

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Advances in Research

According to Tracy Onega, PhD, "African Americans with cancer are less likely to receive the recommended therapy and are about 20% less likely to be alive at the end of three years."

April 25, 2008

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New Vitamin May Relieve a Painful Problem

A pill to protect against nerve damage is a long ways off, but such a drug might also be able to protect against development of other neurodegenerative diseases.

April 20, 2008

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Clinical Research Nurses

When Sara Simeone, RN, talks to a patient about entering a clinical trial, she has one overriding concern—the patient's well-being.

April 10, 2008

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