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Dartmouth Integrative Biology Symposium Invited Speakers

Marisa Bartolomei - University of Pennsylvania

Received her B.S. in Biochemistry at the University of Maryland and then obtained her Ph.D. from the Johns Hopkins University School of Medicine under the guidance of Dr. Jeffry Corden. She trained as a postdoctoral fellow with Dr. Shirley Tilghman at Princeton University. In 1993, Dr. Bartolomei was appointed as an Assistant Professor of Cell and Developmental Biology at the University of Pennsylvania Perelman School of Medicine and was promoted to Associate Professor with tenure in 1999 and Professor in 2006. In 2006, Dr. Bartolomei received the Society for Women's Health Research Medtronics Prize for Contributions to Women's Health. In 2011, Dr. Bartolomei received the Jane Glick Graduate School Teaching Award for the University of Pennsylvania School of Medicine and a MERIT award. She was elected as a Fellow of the American Association for the Advancement of Science in 2014. Dr. Bartolomei participates extensively graduate and medical education, having trained numerous pre- and postdoctoral students, clinicians, and other health care professionals. She is a member of the Human Molecular Genetics and Molecular and Cellular Biology editorial boards and is an Associate editor for PLOS Genetics. Dr. Bartolomei’s research addresses the epigenetic mechanisms of genomic imprinting and X inactivation, as well as the impact of adverse environmental insults on epigenetic gene regulation using the mouse as a model

Schahram Akbarian - Mount Sinai

Professor of Psychiatry and Neuroscience, Chief, Division of Psychiatric Epigenomics with the Icahn School of Medicine at Mount Sinai New York, NY. He is a psychiatrist and molecular neuroscientist who trained at the Massachusetts General Hospital in Boston, the Whitehead Institute for Biomedical Research in Cambridge and the University of California at Irvine. Presently, he heads the Division of Psychiatric Epigenomics in the Departments of Psychiatry and Neuroscience at Mount Sinai School of Medicine. His interests include epigenetic mechanisms and the neurobiology of major psychiatric disorders, including depression, schizophrenia and related neurodevelopmental disease. This includes the exploration of the underlying molecular and cellular pathologies in the diseased brain, and the testing of novel treatments in preclinical model systems. He received awards from National Alliance for Research on Schizophrenia and Depression (NARSAD), the American College of Neuropsychopharmacology (ACNP), the National Alliance for the Mentally Ill (NAMI), and the National Institute of Mental Health. He serves on the scientific advisory board of two private research foundations and on the Editorial board of several journals.

Xiaole Shirley Liu - Harvard University/Dana-Farber

The Director of Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Professor of Biostatistics and Computational Biology, Harvard School of Public Health. She received her Ph.D. in Biomedical Informatics and a Ph.D. minor in Computer Science from Stanford University in 2002 and became assistant professor at the Department of Biostatistics and Computational Biology at Dana-Farber Cancer Institute and Harvard School of Public Health in 2003. Her research focuses on algorithm development and integrative modelling of high throughput genomic data to understand the specificity and function of gene expression regulators in tumor development, progression, drug response and resistance. In computational biology, her laboratory developed widely used algorithms for transcription factor motif finding, ChIP-chip/seq and DNase-seq data analysis. In epigenetics, she and colleagues identified the chromatin signature of embryonic pluripotency and were the pioneers to use the dynamics of nucleosomes and DNase hypersensitivity to predict driving transcription factors and their genome-wide binding in a biological process. In cancer biology, she and colleagues identified novel functions of ESR1, AR, FOXA1, EZH2, and NOTCH1 in various cancers. Liu received the Sloan Research Fellowship in 2008, and was named a Yangtze River Scholar and 1000 Talent Scholar in China in 2012 and 2013, respectively.

Andres Houseman - Oregon State University

A biostatistician focusing on topics in cancer research, environmental exposure assessment and molecular epidemiology. His statistical research involves latent variable methods, model-based clustering, and high-dimensional data analysis, with recent work focusing on computationally efficient methods for epigenomics research. He currently collaborates with Brown and Dartmouth faculty on population-based studies that investigate epigenetic links with environmental exposures, cancer, and mental health outcomes.