A Phase III Randomized Trial of Blinatumomab for Newly Diagnosed BCR-ABL-negative B lineage Acute Lymphoblastic Leukemia in Adults
This randomized phase III trial studies combination chemotherapy with blinatumomab to see how
well it works compared to induction chemotherapy alone in treating patients with newly
diagnosed breakpoint cluster region (BCR)-c-abl oncogene 1, non-receptor tyrosine kinase
(ABL)-negative B lineage acute lymphoblastic leukemia. Drugs used in chemotherapy work in
different ways to stop the growth of cancer cells, either by killing the cells, by stopping
them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal
antibodies, such as blinatumomab, may help the body''s immune system attack the cancer, and
may interfere with the ability of tumor cells to grow and spread It is not yet known whether
combination chemotherapy is more effective with or without blinatumomab in treating newly
diagnosed acute lymphoblastic leukemia.
View more details from ClinicalTrials.gov.
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