Cancer Biology and Therapeutics Program Themes
CBT members are organized by their association with one or more scientific research themes; translation along the continuum from basic research to clinical trials occurs throughout each theme.
- Cancer cell signaling and metabolism. Here, researchers study the relationship between cancer and growth factor receptor, Wnt and Ras signaling, energetics, tissue patterning, and fatty acid metabolism.
- Cell cycle biology and genome stability. This theme includes research on cell cycle checkpoints, phosphorylation and chromosome dynamics during cell division, and chromosome instability.
- Chromatin biology and oncogenic transcription. Genome organization, topological chromatin architecture, transcriptional regulation, enhancers and repressors, and oncogenic transcription factors are key areas of research in this theme.