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Norris Cotton Cancer Center
In This Section

Mouse Modeling (MM)

transgenics and Genetic Constructs

The Transgenic Service supports the generation and utilization of genetically modified mice for members of the Dartmouth research community. We offer a wide variety of services that assist researchers in construct design and creation of novel transgenic mice. We also offer mice with a human immune system that allows our investigators a better way to study viruses and other human infections.

The Speed Congenics Service facilitates the development of congenic mice in support of pre-clinical projects. We provide expert advice on mouse speed congenic development, mouse genetic background analysis and mouse genetic mapping.

PDX Models supports the generation of patient derived xenograft mouse models, the preservation and distribution of the derived tumors and the generation of cohorts of PDX mice in the NSG mouse strain. We further support orthotopic PDX with surgical services and experimental therapies utilizing PDX animals.