Translational Engineering in Cancer

The goal of the Translational Engineering in Cancer Research Program (TEC) is to foster a collaborative environment that promotes the incorporation of imaging, radiobiology, biophysics, and engineering approaches into the development and evaluation of new cancer diagnostic and treatment strategies.

Co-Program Directors:
Keith D. Paulsen, PhD
Brian W. Pogue, PhD

The Translational Engineering in Cancer Research Program continues to thrive as a multidisciplinary group of cancer researchers that includes faculty from The Geisel School of Medicine at Dartmouth, the Thayer School of Engineering, and the clinical departments of Medicine (Radiation Oncology), Surgery, Orthopaedics, Pathology and Radiology within Dartmouth-Hitchcock Medical Center (DHMC).

Program themes

Three research themes within Translational Engineering in Cancer focus on:

  • Surgical Image-Guidance (SIG) to develop molecular and physically-based imaging and measurement techniques for guiding accurate and complete resection of cancers with minimal toxicity and/or complications secondary to surgery.
  • Radiation Monitoring and Guidance (RMG) to develop and assess novel tools to image and measure radiation dose and key physiological/functional parameters that inform and guide the effectiveness and safety of radiotherapy delivery in cancer treatment.
  • Cellular and Molecular Detection and Contrast (CDC) to discover/investigate new approaches to imaging cellular types, metabolites, proteins or nucleotides in vivo and test detection or image contrast based on these with biophysical, parametric, pharmacokinetic or pharmacologic features of tissues, for applications in screening, detection, diagnosis or management of cancer treatment.