Using Estrogen to Treat Breast Cancer

Lead researchers

This research study was led by:

Watch this video to learn about the research behind estrogen therapy options.

Why did we do this research?

The most common breast cancer type is driven by estrogen, a hormone in the body, and successful therapy often blocks the estrogen. Surprisingly, high-dose estrogen therapy can also be effective against previously treated, hormone-receptive metastatic breast cancer. Based on what has been seen in the lab, Drs. Miller and Schwartz wanted to see if alternating high-dose estrogen and blocking estrogen would be beneficial to women with metastatic breast cancer.

What did the research involve?

Drs. Miller and Schwartz enrolled 19 women with metastatic breast cancer who had already received an average of two different treatments. They studied whether alternating high-dose estrogen with blocking estrogen production in the body would slow or stop tumor growth.

What did we learn?

Among the 19 patients in the clinical trial, 16% had their tumors shrink, while 26% had their cancer stabilized for at least 24 weeks. The treatments were well-tolerated, and none of the patients stopped treatment because of side effects.

Why is this important?

Finding the best ways to treat cancer is important. Among the 19 women with advanced cancer in the study, this new treatment was beneficial to almost half of them.

To learn more about this research

For more information about this research, please refer to the following web pages:

Funding acknowledgement

This research was made possible with funds raised by our community through their participation in The Prouty.

Special thanks

We want to thank our Community Research Ambassadors, Laura and Marcy, for partnering with us to develop the video and content for this page. Thanks, Laura and Marcy!