The Cancer Biology and Therapeutics (CBT) Research Program fosters the exchange of ideas, cooperation, interdisciplinary collaborations and acceleration of progress along the translational continuum from basic mechanisms of cancer biology to target discovery, validation and clinical application. The goals of the CBT Program are to:
- Advance understanding of the basic mechanisms that underlie cancer initiation, invasion, progression and metastasis to support prevention, diagnosis and treatment of cancer.
- Identify and validate new pathways and molecular targets for effective therapeutic intervention.
- Facilitate bi-directional translation to develop and improve novel therapeutic and diagnostic strategies.
CBT is a nexus for basic scientists, translational scientists and clinicians with interests in cancer biology and the development of improved treatments and diagnostics. By stimulating interaction and collaboration between investigators across the spectrum from laboratory to clinic, CBT drives bi-directional translation of cancer research.
CBT leaders are integral members of the NCCC Early-Phase Trials Program (EPTP), which provides a path for movement of Dartmouth-initiated laboratory findings from all NCCC Research Programs to the clinic; thus, CBT plays a critical role in the development of investigator-initiated clinical studies. Through partnership with laboratory investigators, physician-researchers that are members of CBT promote the reverse translation of clinical observations back to the laboratory for detailed study. CBT provides a forum to develop and highlight the relevance of innovative model systems and/or Shared Resource services to gain mechanistic insights into the natural history of cancers and therapeutic results.
CBT members are organized by their association with one or more scientific research themes; translation along the continuum from basic research to clinical trials occurs throughout each theme.
- Cancer cell signaling and metabolism. Here, researchers study the relationship between cancer and growth factor receptor, Wnt and Ras signaling, energetics, tissue patterning, and fatty acid metabolism.
- Cell cycle biology and genome stability. This theme includes research on cell cycle checkpoints, phosphorylation and chromosome dynamics during cell division, and chromosome instability.
- Chromatin biology and oncogenic transcription. Genome organization, topological chromatin architecture, transcriptional regulation, enhancers and repressors, and oncogenic transcription factors are key areas of research in this theme.