Borwell Room 322W
Dartmouth Cancer Center
One Medical Center Drive
Lebanon, NH 03756
(603) 650-7811 / (603) 650-8685
Email: Lionel.Lewis@Dartmouth.edu
Pricing information and sample submission
The primary function of the Clinical Pharmacology Shared Resource (CPSR) is to support Dartmouth Cancer Center investigators in the design, analysis, and interpretation of clinical pharmacology objectives in preclinical and clinical studies, including chemoprevention and epidemiological studies. In addition to the biorepository function of our resource, we also have bioanalytical hardware, computer hardware, and state-of-the-art commercial software programs for application to individual and population-based pharmacokinetic and pharmacodynamic modeling, and modeling drug in vitro and in vivo combination drug effects.
Leadership
Lionel D. Lewis, MB, BCh, MD
Director
Professor of Medicine, Pharmacology and Toxicology
Darcy Bates Pooler, PhD
Assistant Director
Instructor in Medicine
Lab Staff
Research Faculty
Darcy Bates Pooler, PhD, Assistant Director, (603) 650-8318 Darcy.Bates@dartmouth.edu
Lab Research Associate
Dylan Ness, BS, (603) 650-7649
Dylan.B.Ness@hitchcock.org
Research Pharmacist
Douglas M. Parr, RPh, PharmD
Administrative Assistant
Margaret J. Kerouac, (603) 650-7811
Margaret.J.Kerouac@hitchcock.org
Clinical Pharmacology services and equipment
Services
- Biorepository, sample collection/receipt, processing, logging, storage and mail out
- Consultation on study design for pharmacokinetic and pharmacodynamic study endpoints
- Analyte measurement in biological samples by HPLC and LC-MS/MS
- Pharmacokinetic and pharmacodynamic data modeling and analysis
- Research pharmacist services
Equipment
- Five 25 cu ft, low-temperature (-80 degree Celsius) freezers
- One 13 cu ft -35 degree Celsius freezer
- Electronic bar coding sample management system
- Varian ProStar LC system with UV and fluorescence detectors
- MJ Research PTC 200 Peltier Thermal Cycler
- State-of-the-art statistical pharmacokinetic /pharmacodynamic modeling software
- LC/MS-MS : Dionex Ultimate 3000 component LC system and Thermo Scientific TSQ (Triple Stage Quadrupole) Vantage Mass Spectrometer
- Dionex Ultimate 3000 variable wavelength and fluorescence detectors
- Immunoblotting: BioRad tetra gel system with Trans-Blot Turbo transfer system