Clinical Pharmacology

Clinical Pharmacology Shared Resource

Borwell Building Room 322W
Dartmouth Cancer Center
One Medical Center Drive
Lebanon, NH 03756
603-650-7811 / 603-650-8685

Pricing information and sample submission

The primary function of the Clinical Pharmacology Shared Resource (CPSR) is to support Dartmouth Cancer Center investigators in the design, analysis and interpretation of pharmacology objectives/endpoints in preclinical and clinical studies, including chemoprevention and epidemiological studies. We have bioanalytical hardware, computer hardware and state-of-the-art commercial software programs for application to individual and population-based pharmacokinetic and pharmacodynamic modeling, and modeling drug in vitro and in vivo combination drug effects. In addition we provide a biosample processing/storage and shipping service. RRID SCR 000873


Lionel D. Lewis, MB, BCh, MD

Lionel D. Lewis, MB, BCh, MD
Professor of Medicine, Pharmacology and Toxicology

Lab staff

Associate Director

Research Pharmacist

Douglas M. Parr, RPh, PharmD

Administrative Assistant

Raelene S. LaPlante, 603-650-7811

Clinical Pharmacology services and equipment


  • Biosample collection/receipt, processing, logging, storage and mail out
  • Consultation on study design for pharmacokinetic and pharmacodynamic endpoints in preclinical and clinical studies
  • Analyte measurement in biological samples using HPLC and LC-MS/MS
  • Pharmacokinetic and pharmacodynamic data modeling and analysis
  • Investigational/research pharmacy services

Equipment/specialist software

  • Four 25 cubic ft., ultra-low temperature (-80 degrees Celsius) freezers
  • Two 13 cubic ft. (-40 degrees Celsius) freezers
  • Two ThermoScience liquid nitrogen Dewars (storage tanks)
  • Electronic bar-coding biosample management system
  • MJ Research PTC 200 Peltier Thermal Cycler
  • LC/MS-MS hardware:-
    1. Thermo Scientific Vanquish Flex UHPLC system and Thermo Scientific TSQ (Triple Stage Quadrupole) Quantis Mass Spectrometer
    2. Dionex Ultimate 3000 HPLC system with variable wavelength and fluorescence detectors and Thermo Scientific TSQ (Triple Stage Quadrupole) Vantage Mass Spectrometer
  • SpectraMax i3x spectrophotometer with injector cartridge
  • Immunoblotting: BioRad tetra gel system with Trans-Blot Turbo transfer system
  • State-of-the-art pharmacokinetic /pharmacodynamic modeling software (Phoenix WinNonlin v8.4)
  • CalcuSyn (by Biosoft) combination drug modeling software
  • Systat v 13.0 statistical software