Clinical Pharmacology

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Clinical Pharmacology Shared Resource

Borwell Room 322W
Norris Cotton Cancer Center
One Medical Center Drive
Lebanon, NH 03756
(603) 650-7811 / (603) 650-8685
Email: Lionel.Lewis@Dartmouth.edu

Pricing information and sample submission

The primary function of the Clinical Pharmacology Shared Resource (CPSR) is to support NCCC investigators in the design, analysis, and interpretation of clinical pharmacology objectives in preclinical and clinical studies, including chemoprevention and epidemiological studies. In addition to the biorepository function of our resource, we also have bioanalytical hardware, computer hardware, and state-of-the-art commercial software programs for application to individual and population-based pharmacokinetic and pharmacodynamic modeling, and modeling drug in vitro and in vivo combination drug effects.

Leadership

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Lionel D. Lewis, MB, BCh, MD

Lionel D. Lewis, MB, BCh, MD
Director
Professor of Medicine, Pharmacology and Toxicology

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Darcy Bates Pooler, PhD

Darcy Bates Pooler, PhD
Assistant Director
Instructor in Medicine

Lab Staff

Research Faculty

Darcy Bates Pooler, PhD, Assistant Director, (603) 650-8318 Darcy.Bates@dartmouth.edu

Lab Research Associate

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Dylan Ness, BS

Dylan Ness, BS, (603) 650-7649
Dylan.B.Ness@hitchcock.org

Research Pharmacist

Douglas M. Parr, RPh, PharmD

Administrative Assistant

Margaret J. Kerouac, (603) 650-7811 
Margaret.J.Kerouac@hitchcock.org

Clinical Pharmacology services and equipment

Services

  • Biorepository, sample collection/receipt, processing, logging, storage and mail out
  • Consultation on study design for pharmacokinetic and pharmacodynamic study endpoints
  • Analyte measurement in biological samples by HPLC and LC-MS/MS
  • Pharmacokinetic and pharmacodynamic data modeling and analysis
  • Research pharmacist services

Equipment

  • Five 25 cu ft, low-temperature (-80 degree Celsius) freezers
  • One 13 cu ft -35 degree Celsius freezer
  • Electronic bar coding sample management system
  • Varian ProStar LC system with UV and fluorescence detectors
  • MJ Research PTC 200 Peltier Thermal Cycler
  • State-of-the-art statistical pharmacokinetic /pharmacodynamic modeling software
  • LC/MS-MS : Dionex Ultimate 3000 component LC system and Thermo Scientific TSQ (Triple Stage Quadrupole) Vantage Mass Spectrometer
  • Dionex Ultimate 3000 variable wavelength and fluorescence detectors
  • Immunoblotting: BioRad tetra gel system with Trans-Blot Turbo transfer system