The Transgenic Service supports the generation and utilization of genetically modified mice for members of the Dartmouth research community. We offer a wide variety of services that assist researchers in construct design and creation of novel transgenic mice. We also offer mice with a human immune system that allows our investigators with a better way to study viruses and other human infections.
PDX Models supports the generation of patient-derived xenograft mouse models, the preservation and distribution of the derived tumors and the generation of cohorts of PDX mice in the NSG mouse strain. We further support orthotopic PDX with surgical services and experimental therapies utilizing PDX animals.